Molecular mechanism of TSLP production in keratinocytes in atopic dermatitis
Molecular mechanism of TSLP production in keratinocytes in atopic dermatitis
批准号:
23659546
负责人:
AKIYAMA Masashi
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
胸腺基质淋巴生成素(TSLP)是角质形成细胞分泌的特应性皮炎(AD)发病机制中最重要的趋化因子之一。然而,哪种刺激诱发TSLP并不是很好的识别。在本研究中,我们认为角质形成细胞中的未折叠蛋白反应可诱导TSLP。
英文摘要
Thymic stromal lymphopoietin (TSLP) is one of the most important chemokine for pathogenesis of atopic dermatitis (AD), which is secreted by keratinocytes. However, which kinds of stimuli induce TSLP is not unidentified well. In this study, we suggested the unfolded protein response in keratinocytes induce TSLP.
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角層バリア機能異常症としての角化症とフィラグリン シンポジウム「Fillagrinとアトピー性皮膚炎」
角化病和填充蛋白作为角质层屏障功能障碍疾病研讨会“填充蛋白和特应性皮炎”
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Akiyama M, 秋山真志]
通讯作者:
秋山真志
今、注目される遺伝性皮膚バリア障害 シンポジウム「遺伝性皮膚疾患」
现在备受关注的遗传性皮肤屏障疾病研讨会“遗传性皮肤病”
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Akiyama M, 秋山真志, 秋山真志, 秋山真志, 秋山真志, 秋山真志, 秋山真志]
通讯作者:
秋山真志
DOI:
10.3109/08923973.2012.733707
发表时间:
2013-02
期刊:
Immunopharmacology and Immunotoxicology
影响因子:
3.3
作者:
[A. Saito;Y. Muro;K. Sugiura;M. Akiyama]
通讯作者:
A. Saito;Y. Muro;K. Sugiura;M. Akiyama
LEDGF/DFS70 activates the MK2/IL6/STAT3 pathway in HaCaT
LEDGF/DFS70 激活 HaCaT 中的 MK2/IL6/STAT3 通路
DOI:
10.1016/j.jdermsci.2011.05.004
发表时间:
2011
期刊:
J Dermatol Sci
影响因子:
4.6
作者:
[Tazawa H, Irei T, Igarashi Y, Tanaka Y, Ohdan H, Suda T, Takeichi T]
通讯作者:
Takeichi T
ABCA12機能障害による先天性魚鱗癬様紅皮症の発症機序の解明と治療法の開発
ABCA12功能障碍所致先天性鱼鳞病样红皮病发病机制的阐明及治疗方法的开发
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[Fukuda, A., 秋山真志]
通讯作者:
秋山真志
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Elucidation of novel pathomechanisms due to defects in remote enhancers and chromatin domain TADs in genodermatosis
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Elucidation of pathogenesis and development of novel therapy of chilblain lupus on the basis of an exonuclease enzyme
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Crystal structure analysis for the pathogenesis of thrombosis
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Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.
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