Development of new surgical approach for neurogenic pain using in situ Tissue Engineering.

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This project was performed in an attempt to reveal mechanism of recovering of causalgie with animal experiment. The causalgie has been recently found to be able to be reliefed surgically by means of local repair of damaged peripheral nerves with an aid of in situ Tissue Engineering.Achieved results of this project were as followings :(1) The effect did not remain in the damaged part, reached widely along the nerve trunks both distally and proximally, more widely and longer large than we believed previously.(2) It was extremely difficult to access the action potential on C fibers, hence the importance of establishment of reliable measurement system of action potential C fiber was recognized.(3) Reaction of regenerated nerve induced by sensory-touch, sensory-heat, sensory mechanical stimulation were evaluated, especially on the change of threshold revel of C fiber and after discharges. Change of C NAP (Compound Nerve Action Potential) was measured after shut-down with compression of the extremities with manschett, which indicated the precise process of non-injured peripheral nerves in each recovery phase.