Study of vitreous body : Analysis of microenvironmental control and development of novel treatment.

本文从玻璃体视网膜疾病的发病机制、分子机制和治疗等方面进行了研究。首先，分析玻璃体内损伤相关分子模式与视网膜损伤的关系。因此，视网膜病理不仅受到细胞因子等生物活性分子的强烈影响，而且受到受损细胞及其相关蛋白的强烈影响。使用KO动物的实验治疗非常有效。目前的发现对于开发具有最小组织损伤的新治疗是非常有益的。

We performed the study of vitreoretinal diseases from the points of its pathogenesis, molecular mechanism, and treatment. First, the relationship between intravitreous damage-associated molecular pattern and retinal damage was analyzed. As a result, retinal pathology was strongly affected not only by bioactive molecules such as cytokines, but rather by damaged cells and its related proteins. The experimental treatment using KO animals was very effective. The present findings are quite beneficial for developing a new treatment with minimal tissue damage.