Biology of Vitreous Body : Development of new treatment for chorioretinal diseases by controlling vitreous body

玻璃体生物学：通过控制玻璃体开发脉络膜视网膜疾病的新疗法

• 批准号: 17390469
• 负责人: SAKAMOTO Taiji
• 金额: $ 10.67万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390469/
• 关键词: Hyalocvte; Ultrasound; gene transfer; CRP; VEGF; 硝子体手術

The purpose of this project was to investigate the biology of vitreous body, which was not been wellstudied, and to develop new treatments for chorioretinal diseases. The following results were obtained during the study period. Although this may be just the beginning, it will be an important study field from now on.1.Vitreous body biology: Characteristics of resident cells in the vitreous body (hyalocytes) were studied. The origin of hyalocytes was found to be a bone marrow and hylocytes turned over in 3 months. Most of them were located on vitreo-retinal interface area. We found that there is a specific immune-system called vitreous cavity-associated immune deviation (VCAID). Hyalocytes were major players to identify antigens. There are the new findings.2. Role of vitreous body in pathogenesis of diseases : Vitreous body was found to affect the progression of retinal diseases. In macular hole, the invasion of glial cells into the vitreous body played a pivotal role. In diabetic retinopathy, the increase of SDF-I and VEGF deteriorated the disease progression.3. Development of new treatment using vitreous body biology : Visualizing adjuvant for vitreous body was developed and it was used for various disesetreatment. The results showed that the new method is superior to perform the vitreo-retinal surgery safely and securely.

该项目的目的是研究玻璃体的生物学，该生物学并未得到充分研究，并为脉络膜视网膜疾病开发新的治疗方法。在研究期间获得以下结果。尽管这可能只是开始，但从现在开始，它将是一个重要的研究领域。1。维特尔身体生物学：玻璃体体内居民细胞的特征（透明细胞）。发现透明质细胞的起源是骨髓，并在3个月内翻转。他们中的大多数位于玻璃体视网膜接口区域。我们发现有一个特定的免疫系统称为玻璃体相关的免疫偏差（VCAID）。透明细胞是识别抗原的主要参与者。有新发现2。玻璃体体在疾病的发病机理中的作用：发现玻璃体体会影响视网膜疾病的进展。在黄斑孔中，神经胶质细胞进入玻璃体体的侵袭起着关键作用。在糖尿病性视网膜病中，SDF-I和VEGF的增加使疾病进展恶化3。使用玻璃体生物学的新处理开发：开发了可视化玻璃体体的佐剂，并用于各种疾病。结果表明，新方法更优于安全，安全地进行玻璃体视网膜手术。

项目成果

Two cases of IOL implantation with injection devices

注射器人工晶状体植入术二例

• 发表时间: 2007
• 作者: Otsuji;F;Sonoda;Y;Sakamoto;T
• 通讯作者: T

SIVベクターを用いたヒトPEDF遺伝子発現による網膜神経節細胞保護効果

使用SIV载体表达人PEDF基因对视网膜神经节细胞的保护作用

• 发表时间: 2006
• 作者: 宮崎 勝徳;池田 康博;米満 吉和;向野 利一郎;後藤 純伸;坂本 泰二;長谷川 護;居石 克夫;石橋 達朗
• 通讯作者: 石橋 達朗

Three cases of neovascular glaucoma treated by cilicary body photocoagulation

睫状体光凝治疗新生血管性青光眼三例

• 发表时间: 2007
• 作者: Tanaka;Y;Yamashita;T;Yamakiri;K;Sakamoto;T
• 通讯作者: T

Three cases of macular hole diagnosed by FD-OCT

FD-OCT诊断黄斑裂孔三例

• 发表时间: 2007
• 作者: Sonoda;Y;Doi;N;Yamakiri;K;Sakamoto;T
• 通讯作者: T

インジェクターを用いて眼内レンズを挿入・縫着した2症例

使用注射器插入并缝合人工晶状体的两个案例

• 发表时间: 2007
• 作者: 尾辻 太;園田 恭志;坂本 泰二
• 通讯作者: 坂本 泰二