Biology of Vitreous Body : Development of new treatment for chorioretinal diseases by controlling vitreous body

该项目的目的是研究玻璃体的生物学，这是没有得到很好的研究，并开发新的治疗脉络膜视网膜疾病。在研究期间获得了以下结果。虽然这可能只是一个开始，但它将是今后的一个重要研究领域。1.玻璃体生物学：研究了玻璃体中驻留细胞（透明细胞）的特性。透明细胞的来源是骨髓，透明细胞在3个月内发生转化。多位于玻璃体视网膜界面区。我们发现有一种特殊的免疫系统，称为玻璃体腔相关免疫偏离（VCAID）。透明细胞是识别抗原的主要参与者。有新的发现。玻璃体在疾病发病机制中的作用：发现玻璃体影响视网膜疾病的进展。在黄斑裂孔中，胶质细胞侵入玻璃体起着关键作用。在糖尿病视网膜病变中，SDF-I和VEGF的升高加重了疾病的进展.利用玻璃体生物学开发新的治疗方法：开发了玻璃体可视化辅助剂，用于各种疾病的治疗。结果表明，该方法是一种安全、可靠的玻璃体视网膜手术的上级方法。

The purpose of this project was to investigate the biology of vitreous body, which was not been wellstudied, and to develop new treatments for chorioretinal diseases. The following results were obtained during the study period. Although this may be just the beginning, it will be an important study field from now on.1.Vitreous body biology: Characteristics of resident cells in the vitreous body (hyalocytes) were studied. The origin of hyalocytes was found to be a bone marrow and hylocytes turned over in 3 months. Most of them were located on vitreo-retinal interface area. We found that there is a specific immune-system called vitreous cavity-associated immune deviation (VCAID). Hyalocytes were major players to identify antigens. There are the new findings.2. Role of vitreous body in pathogenesis of diseases : Vitreous body was found to affect the progression of retinal diseases. In macular hole, the invasion of glial cells into the vitreous body played a pivotal role. In diabetic retinopathy, the increase of SDF-I and VEGF deteriorated the disease progression.3. Development of new treatment using vitreous body biology : Visualizing adjuvant for vitreous body was developed and it was used for various disesetreatment. The results showed that the new method is superior to perform the vitreo-retinal surgery safely and securely.