Periodontal system biology: analysis of molecular bases of periodontal disease associated genes.
Periodontal system biology: analysis of molecular bases of periodontal disease associated genes.
批准号:
20390529
负责人:
YAMADA Satoru
金额:
$11.81万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
本研究构建了牙周系统生物学网络数据库(PsBND),并与其他基因表达数据库进行比较分析,以确定牙周韧带特异性基因。我们发现了新的骨膜蛋白亚型,谷氨酸信号相关分子诱导的机械应力和PLAP-1牙周韧带特异性。功能分析表明,这些分子协调,以保持牙周膜组织的稳态。
英文摘要
this study, we constructed the periodontal system biology network database (PsBND) and analyzed the PsBND database comparing with other gene expression databases in order to identify periodontal ligament-specific genes. We found novel Periostin isoforms, glutamate-signaling associated molecules induced by mechanical stress and PLAP-1 periodontal ligament-specific. Functional analysis revealed that these molecules harmonized to keep homeostasis of periodontal ligament tissues.
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ヒト歯根膜組織完全長cDNAライブラリーを用いたCathepsin Kの同定および機能解析
人牙周膜组织全长cDNA文库对组织蛋白酶K的鉴定及功能分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[尾崎亘弘, 山田聡, 藤原千春, 田内拓史, 梶川哲宏, 粟田敏仁, 小澤康宏, 村上伸也]
通讯作者:
村上伸也
Cathepsin K expression in human periodontal ligament cells
组织蛋白酶 K 在人牙周膜细胞中的表达
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ozaki N, Yamada S, Fujihara C, Tauchi T, Kajikawa T, Awata T, Ozawa Y Murakami S]
通讯作者:
Ozawa Y Murakami S
DOI:
10.1074/jbc.m109.097303
发表时间:
2010-09-03
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Fujihara, Chiharu, Yamada, Satoru, Murakami, Shinya]
通讯作者:
Murakami, Shinya
歯周組織恒常性維持の分子基盤研究 -歯根膜特異的分子PLAP-1の解析-
维持牙周组织稳态的分子基础研究-牙周膜特异性分子PLAP-1分析-
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[G.Ganburged, et al, 山田聡]
通讯作者:
山田聡
Gene polymorphism in PLAP-1/asporin regulates mineralization of periodontal ligament cells.
PLAP-1/asporin 的基因多态性调节牙周膜细胞的矿化。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kajikawa T, Yamada S, Murakami S]
通讯作者:
Murakami S
共 11 条
Feasible research for novel periodontal regeneration therapeutics by CRISPR/Cas9
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批准号:16K15846
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.16万
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财政年份:2016
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负责人:YAMADA Satoru
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依托单位:
Web-based interactive 3D electromagnetic visualization for education
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批准号:24501076
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2012
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负责人:YAMADA Satoru
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依托单位:
Development of novel minimal intervention methods for periodontal tissue regeneration therapy
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批准号:22659379
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.08万
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财政年份:2010
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负责人:YAMADA Satoru
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依托单位:
Construction of the disaster nursing support network system
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批准号:21390570
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.83万
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财政年份:2009
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负责人:YAMADA Satoru
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依托单位:
A study of the operative system to utilize nursing man power in the disaster support effectively.
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批准号:18390580
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.94万
-
财政年份:2006
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负责人:YAMADA Satoru
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依托单位:
A research on construction and evaluation of disaster nursing support network in disaster frequent occurrence Prefecture
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批准号:14370812
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$2.94万
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财政年份:2002
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负责人:YAMADA Satoru
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依托单位:
Developing Classifications of Psychiatric Nursing Problems and Interventions for Electronic Nursing Records
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批准号:14370820
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.26万
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财政年份:2002
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负责人:YAMADA Satoru
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依托单位:
Preparation of the nursing guideline in the disaster and research on the nursing support network in disaster frequent occurrence Prefecture.
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批准号:12470537
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.17万
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财政年份:2000
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负责人:YAMADA Satoru
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依托单位:
Project study of tissue regeneration with tissue engineering
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批准号:12307051
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$25.43万
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财政年份:2000
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负责人:YAMADA Satoru
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依托单位:
The Mechanisms of Plaque-induced Lesion of Peri-implantitis
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批准号:08457511
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.14万
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财政年份:1996
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负责人:YAMADA Satoru
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依托单位:
The study on the regeneration of periodontium on the portion of periodontal disease
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批准号:07307032
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$3.71万
-
财政年份:1995
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负责人:YAMADA Satoru
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依托单位:
Development of Bioabsorbable membrane with guided tissue regenevatlar
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批准号:06454545
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.69万
-
财政年份:1994
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负责人:YAMADA Satoru
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依托单位:
A study of Artificial Implantation in Periodontal Osseous Defects
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批准号:63480425
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.56万
-
财政年份:1988
-
负责人:YAMADA Satoru
-
依托单位:
海外基金