Development of Bioabsorbable membrane with guided tissue regenevatlar

本研究评价了可吸收膜(聚[乳酸-羟基乙酸])在引导组织再生技术(GTR)中的临床效果。60例以晚期牙周炎为主的成人牙周炎患者，包括角状骨缺损、2壁、3孔和复合性骨下缺损以及I类、II类和III类分叉缺损。该组包括22名男性和38名女性；年龄从24岁到68岁不等，平均年龄为48岁。在治疗的卫生阶段结束后，记录临床测量，包括探查深度和临床附着水平。骨缺损通过手术暴露出来。创面采用开放瓣清创加可吸收牙周膜修复。术后6个月复查临床资料。术后愈合情况平平。覆盖装置的软组织发炎或其他与这种可吸收膜有关的不良事件在任何患者中都没有见过。平均探诊深度由5.7 mm降至2.9 mm，平均探诊深度减少2.8 mm(P&lt；0.001)。相对附着水平由平均9.0 mm提高到6.8 mm，探测性附着平均增加2.2 mm(P&lt；0.001)。牙龈退缩最小，平均为0.6 mm。这些结果表明，可吸收膜(聚[乳酸-甘草酸])在牙周炎的治疗中是有价值的。

This investigation assessed the clinical efficacy of absorbable membrane (Poly [lactic acid-co-glycolic acid]) on the guided tissue regeneration technique (GTR). A total of 60 patients with mainly advanced adult periodontitis, including lesions with angular bony defects, 2-wall, 3-well and compound infrabony defects and class I,class II and class III furcation defects, were studied. The group included 22 males and 38 females ; ages ran-ged from 24 to 68 years with a mean age of 48 years. Following completion of the hygienic phase of treatment, clinical measurements including probing depth and clinical attachment level were recorded. Bone defects were surgically exposed. Defects were treated with open flap debridement plus absorbable periodontal membrane. Six months postsurgery, clinical data were rerecorded. Postsurgical healing was uneventful. Inflammation of the soft tissue covering the device or othere adverse events related to this absorbable membrance have not seen in any patients. Mean probing depth was reduced from 5.7mm to 2.9mm, with a mean probing depth reduction of 2.8mm (P<0.001). Relative attachment level was improved from an average of 9.0mm to 6.8mm, with a mean gain of probing attachment of 2.2mm (P<0.001). There was minimal gingival recession, averaging 0.6mm.These results suggest that the absorbable membranes (Poly [lactic acid-co-glycoric acid]) used in the GTR procedure are valuable in the treatment of adult periodontitis.