Exploration of biological marker of insomnia

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We evaluated the changes of sleep-wake promoting substances in the cerebrospinal fluid (CSF) and serum of patients with sleep disorders carry out with the sleep research group at Zurich University. Lipocalin-type prostaglandin D synthase (L-PGDS) levels in CSF of narcoleptic patients were significantly lower than those of the control, while those from patients with Parkinson's disease were significantly higher as compared with those of the control. As compared with the CSF of the controls, histamine levels in CSF of patients with multiple sclerosis were significantly higher and so as the inosine level in CSF of patients with sleep disorders. These results indicated that L-PGDS, histamine and inosine are new biological marker of sleep disorders.