Epidemiological and virological studies on avian influenza virus H5N1 in Egypt

埃及H5N1禽流感病毒流行病学和病毒学研究

• 批准号: 20406025
• 负责人: IKUTA Kazuyoshi
• 金额: $ 10.73万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20406025/
• 关键词: 鳥インフルエンザウイルス; エジプト; アレキサンドリア大学; ニワトリ; アヒル; ハト; 遺伝子配列; 病原性

Highly pathogenic avian influenza A virus (HPAIV H5N1) is currently widespread in several areas. Although the current H1N1 pandemic may have diverted attention from the continuing worldwide circulation of H5N1 virus, the pandemic threat of H5N1 is still alarming. In particular, Egypt has unexpectedly had the highest number of human cases of H5N1 infection. In this study, we conducted a molecular-epidemiological studies using H5N1 viruses isolated between 2006 and 2008-2009 in Egypt. The phylogenetic results showed that recent human isolates clustered into several new H5 sublineages. As expected, we found that these H5 sublineages have acquired an enhanced binding affinity for α2, 6SA.

高致病性甲型禽流感病毒（HPAIV H5N1）目前在若干地区广泛传播。虽然目前的H1N1大流行可能转移了人们对H5N1病毒在世界范围内持续传播的注意力，但H5N1的大流行威胁仍然令人震惊。特别是，埃及出人意料地出现了最多的人感染H5N1病例。在这项研究中，我们使用2006年至2008-2009年间在埃及分离的H5N1病毒进行了分子流行病学研究。系统发育结果表明，最近的人类分离株聚集在几个新的H5亚谱系中。正如预期的那样，我们发现这些H5亚系对α 2,6sa具有增强的结合亲和力。

项目成果

Host-specific genetic variation of highly pathogenic avian influenza viruses (H5N1).

• DOI: 10.1007/s11262-011-0583-y
• 发表时间: 2011-06
• 期刊: VIRUS GENES
• 影响因子: 1.6
• 作者: Ibrahim, Madiha Salah;Watanabe, Yohei;Ellakany, H. F.;Yamagishi, Aki;Sapsutthipas, Sompong;Toyoda, Tetsuya;El-Hamied, H. S. Abd;Ikuta, Kazuyoshi
• 通讯作者: Ikuta, Kazuyoshi

Ramasoota P.Fab MAbs specific to HA of influenza virus with H5N1 neutralizing activity selected from immunized chicken phage library.

Ramasoota P.Fab 单克隆抗体对流感病毒 HA 具有 H5N1 中和活性，选自免疫鸡噬菌体库。

• 发表时间: 2010
• 期刊: Biochem.Biophys.Res.Commun. 395
• 作者: Pitaksajjakul P;Lekcharoensuk P;Uparagarin N;Barbas CF;3^;Ibrahim MS;Ikuta K
• 通讯作者: Ikuta K

エジプトで流行するH5N1高病原性鳥インフルエンザウイルスのヒト型レセプター結合親和性獲得に関与する変異

埃及流行的高致病性H5N1禽流感病毒与人类受体结合亲和力的获得有关的突变

• 发表时间: 2010
• 作者: 渡辺洋平;M.S.Ibrahim;川下理日人;H.F.Ellakany;N.Scriwilaijaroen;平松宏明;鈴木康夫;生田和良
• 通讯作者: 生田和良

Development of Two Types of Rapid Diagnostic Test Kits To Detect the Hemagglutinin or Nucleoprotein of the Swine-Origin Pandemic Influenza A Virus H1N1

• DOI: 10.1128/cvi.00269-10
• 发表时间: 2011-03-01
• 期刊: CLINICAL AND VACCINE IMMUNOLOGY
• 作者: Mizuike, Rika;Sasaki, Tadahiro;Ikuta, Kazuyoshi
• 通讯作者: Ikuta, Kazuyoshi

Acquisition of human-type receptor binding specificity by new H5N1 influenza virus sublineages during their emergence in birds in Egypt.

新的H5N1流感病毒在埃及鸟类出现期间，通过新的H5N1流感病毒sublineage的特异性获得了人类型受体结合的特异性。

• DOI: 10.1371/journal.ppat.1002068
• 发表时间: 2011-05
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Watanabe Y;Ibrahim MS;Ellakany HF;Kawashita N;Mizuike R;Hiramatsu H;Sriwilaijaroen N;Takagi T;Suzuki Y;Ikuta K
• 通讯作者: Ikuta K