A Molecular-epidemiological study of oral and maxillofacial disease among the residents living in Semipalatinsk nuclear test site in Kazakhstan

哈萨克斯坦塞米巴拉金斯克核试验场居民口腔颌面部疾病的分子流行病学研究

• 批准号: 20406030
• 负责人: OKAMOTO Tetsuji
• 金额: $ 10.57万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20406030/
• 关键词: セミパラチンスク核実験場; 低線量放射線被ばく; 先天異常; 分子疫学; 遺伝子多型; 口腔疾患罹患率; 唇顎口蓋裂発症率; 顎口腔顔面疾患; 低線量被ばく; インターロイキン１; 歯周病; 顎顔面口腔疾患; 口腔常在菌; ヘリコバクターピロリ菌; 低線量被曝; 先天奇形; Tie-2; 唇顎口蓋裂; 歯周疾患; 口唇口蓋裂; 放射線影響; 核実験; カザフスタン共和国; 放射能被爆; IL-1α(889)遺伝子多型; IL-1β(-511)遺伝子多型 /

From1949 to 1989, 30 surface, 88 atmospheric and 340 underground nuclear and thermonuclear explosions of nuclear weapons were carried out by former Soviet Union at the Semipalatinsk Nuclear Test Site (SNTS) in Kazakhstan that resulted in high local fallout affecting the residents in the villages adjacent to the SNTS. The radiation effect on predisposition of oral and maxillofacial disorders among the exposed people from the SNTS areas remains unknown. The purpose of this study is to investigate a possible relationship between long-term radiation exposure by nuclear testing and predisposition of Oral maxillofacial anomalies such as Cleft lip & Palate (CLP) and oral diseases such as periodontitis. In conclusion, this study strongly suggests that the inhabitants in exposed villages adjacent to SNTS might be considered a population at risk for high prevalence oforal & maxillofacial lesions. It is possible that this heightened risk resulted from long-term radiation exposure.

1949年至1989年间，前苏联在哈萨克斯坦塞米巴拉金斯克核试验场（SNTS）进行了30次地面、88次大气层和340次地下核爆炸和热核爆炸，造成了严重的局部辐射影响，影响了SNTS附近村庄的居民。辐射对 SNTS 地区受辐射人群口腔颌面部疾病易感性的影响仍不清楚。本研究的目的是调查核试验的长期辐射暴露与唇腭裂（CLP）等口腔颌面部异常和牙周炎等口腔疾病的易感性之间可能存在的关系。总之，这项研究强烈表明，SNTS 附近暴露村庄的居民可能被认为是口颌面部病变高患病率的人群。这种风险增加可能是由于长期接触辐射造成的。

项目成果

Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells

• DOI: 10.1038/emboj.2010.26
• 发表时间: 2010-04-07
• 期刊: EMBO JOURNAL
• 影响因子: 11.4
• 作者: Matsumoto, Shinji;Fumoto, Katsumi;Kikuchi, Akira
• 通讯作者: Kikuchi, Akira

FGFRI abrogates inhibitory effect of androgen receptor concurrent with induction of androgen-receptor variants in androgen receptor-negative prostate tumor epithelial cells.

FGFRI 消除雄激素受体的抑制作用，同时诱导雄激素受体阴性前列腺肿瘤上皮细胞中雄激素受体变异。

• 发表时间: 2011
• 期刊: Prostate,doi : 10.1002/pros.21386 (Epub ahead of print)
• 作者: Kobayashi M;Huang Y;Okamoto T Wang;F;McKeehan WL.;et al.
• 通讯作者: et al.

Participation of heterodimer formation with integrin αv subunit in the stability of integrin β8 subunit in squamous cell carcinoma cells

整合素αv亚基形成异二聚体参与鳞状细胞癌细胞整合素β8亚基稳定性

• 发表时间: 2013
• 作者: Fujii T.;Hayashido Y.;Hamana T.;Sakaue T. and Okamoto T.
• 通讯作者: Sakaue T. and Okamoto T.

Analysis of binding site of ubiquitin ligase, human double minute 2 in integrinβ8

整合素β8中泛素连接酶、人双分钟2的结合位点分析

• 发表时间: 2012
• 作者: Sakaue T;Hayashido Y;Hamana T;Fujii T;Okamoto T
• 通讯作者: Okamoto T

Long-term serial cultivation of mouse induced pluripotent stem cells in serum-free and feeder-free defined medium

• DOI: 10.1387/ijdb.130173to
• 发表时间: 2013-01-01
• 期刊: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
• 影响因子: 0.7
• 作者: Yamasaki, Sachiko;Nabeshima, Kou;Okamoto, Tetsuji
• 通讯作者: Okamoto, Tetsuji