A Molecular-epidemiological study of oral and maxillofacial disease among the residents living in Semipalatinsk nuclear test site in Kazakhstan

从1949年到，前苏联在哈萨克斯坦塞米巴拉金斯克核试验场进行了88次地面、88次大气层和340次地下核热核爆炸，导致当地严重的放射性尘埃影响到与核试验场相邻的村庄的居民。辐射对SNTS地区暴露人群口腔颌面部疾病易感性的影响尚不清楚。本研究旨在探讨长期核辐射暴露与唇腭裂等口腔颌面部畸形及牙周炎等口腔疾病易感性之间的关系。综上所述，这项研究强烈表明，与SNTS相邻的暴露村庄的居民可能被认为是口腔颌面部病变高发人群。这种风险的增加可能是由于长期的辐射暴露造成的。

From1949 to 1989, 30 surface, 88 atmospheric and 340 underground nuclear and thermonuclear explosions of nuclear weapons were carried out by former Soviet Union at the Semipalatinsk Nuclear Test Site (SNTS) in Kazakhstan that resulted in high local fallout affecting the residents in the villages adjacent to the SNTS. The radiation effect on predisposition of oral and maxillofacial disorders among the exposed people from the SNTS areas remains unknown. The purpose of this study is to investigate a possible relationship between long-term radiation exposure by nuclear testing and predisposition of Oral maxillofacial anomalies such as Cleft lip & Palate (CLP) and oral diseases such as periodontitis. In conclusion, this study strongly suggests that the inhabitants in exposed villages adjacent to SNTS might be considered a population at risk for high prevalence oforal & maxillofacial lesions. It is possible that this heightened risk resulted from long-term radiation exposure.