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Molecular Epidemiological studu of Oral and Maxillofacial disorders among the residents of the Semipalatinsk Nuclear Test Site Area

塞米巴拉金斯克核试验场地区居民口腔颌面部疾病的分子流行病学研究

基本信息

批准号：
12576025
负责人：
OKAMOTO Tetsuji
金额：
$ 9.54万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

From 1949 to 1989, 30 surface, 88 atmospheric and 340 underground nuclear and thermonuclear explosions of nuclear weapons were carried out at the Semipalatinsk Nuclear Test Site (SNTS). The aim of this study was to investigate the radiation effect to the maxillo-facial region in the heavily exposed and control population of similar ages (<10 years old) at the time of most harmful atmospheric nuclear weapons testing in 1949-1956. We have found an apparently strong association between radioactive fallout exposure and the high frequency of tooth loss due to severe periodontitis among the screened population from exposed villages Sarzhal and Dolon. This study suggests more detailed molecular research of the nature of tooth loss in the heavily exposed population. In the screened inhabitants from heavily exposed villages Sarzhal and Dolon the high average number of missing teeth was observed in all genotype polymorphisms and statistically were not associated. The high frequency of tooth loss due to severe periodontitis among the inhabitants from the heavily exposed villages Sarzhal and Dolon may be related to the harmful environmental influence, including ionizing radiation. The significance of factor A (p<0.001), which implies the degree of environmental differences in the population from Sarzhal, Dolon and Kokpekty ; the same ethnicity, oral hygiene, nutritional and smoking habit of the inhabitants from the exposed and control villages support this conclusion as well. Inhabitants from the exposed villages Sarzhal and Dolon might be considered as a population at risk for high frequency of tooth loss as a result of radiation exposure and further follow-up study is needed for them. This study suggests more detailed molecular research of the nature of dental disorders in the area surrounding the SNTS.

1949年至1989年，塞米巴拉金斯克核试验场共进行了30次地面、88次大气层和340次地下核热核爆炸。本研究的目的是调查1949-1956年进行危害最大的大气核武器试验时，重度暴露人群和年龄相近的对照人群(10岁)对颌面部的辐射效应。我们发现放射性尘埃暴露与来自Sarzhal和Dolon村的筛查人群中因严重牙周炎而导致的高频率牙齿缺失之间存在明显的强烈关联。这项研究建议对严重暴露人群中牙齿脱落的性质进行更详细的分子研究。在重度暴露村Sarzhal和Dolon的筛查居民中，所有基因多态的平均缺牙数都很高，在统计学上没有相关性。严重暴露的Sarzhal和Dolon村居民因严重牙周炎导致牙齿脱落的频率较高，可能与包括电离辐射在内的有害环境影响有关。A因子(p&lt；0.001)的重要性也支持这一结论，A因子暗示了Sarzhal、Dolon和Kokpekty人口的环境差异程度；暴露村庄和对照村庄居民的种族、口腔卫生、营养和吸烟习惯相同。来自受辐射村庄Sarzhal和Dolon的居民可能被认为是辐射暴露导致高频率牙齿缺失的危险人群，需要对他们进行进一步的后续研究。这项研究建议对SNTS周围地区牙科疾病的性质进行更详细的分子研究。