The influence and action of antioxidant vitamin supplementation on thermoregulatory vasomotion in human skin

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To elucidate the influence and action mechanism of antioxidant vitamin supplementation on thermoregulatory vasomotor function in human skin, we administered vasoactive agents with and without vitamin C in forearm skin and examined the vasomotor responses at the treated skin sites during thermal stress. The present study suggests that antioxidant vitamin supplementation increases the vasodilator response during whole-body heating but does not alter the vasoconstrictor response during whole-body cooling, while it inhibits the vasoconstrictor response to local skin cooling through adrenoceptor-dependent mechanism.