Role of pro-peptide region as an intra-molecular chaperone and its application

研究了肽类激素前肽区作为分子内伴侣的作用，以阐明肽类激素在发育过程中的结构与功能关系。prourogunaylin的折叠和X-射线结构分析表明，分子内伴侣起着至关重要的作用，维护的生物活性位点的局部稳定性相关的前体分子在其发展过程中的净稳定。

Role of propeptide-region of peptide hormone as an intra-molecular chaperone was investigated to elucidate structure-function relationship of peptide hormone during its development. Folding and X-ray structural analyses of prourogunaylin revealed that intra-molecular chaperon plays a critical role for the maintenance of the local stability of the biologically active site related to the net stabilization of the precursor molecule during its development.