Synthesis of a new metal complex bearing N-heterocyclic carbenes and its application to catalytic asymmetric reaction

以手性β-氨基醇为原料，发展了一系列羟基酰胺基咪唑盐如碘化咪唑和氯化咪唑的合成路线。对于作为NHC的唑鎓化合物与钯的配位，采用基于借助于NHC-Ag络合物中间体的配体转移的策略。因此，已经成功地合成了多种NHC-Pd配合物。这些NHC-Pd配合物的分子结构的细节，通过单晶X-射线衍射研究建立。手性二聚三齿烷氧基/酰胺基/NHC钯（II）配合物在室温下可催化芳基硼酸与无环烯烃的Heck型氧化反应，得到了高对映选择性的偶联产物.

The efficient synthetic routes to a series of hydroxy-amide-functionalized azolium salts such as azolium iodides and chlorides from chiral β-amino alcohols have been developed. For coordination of the azolium compound as NHC to palladium, the strategy based on the ligand transfer with the aid of a NHC-Ag complex intermediate was employed. Thus, a wide variety of NHC-Pd complexes have been successfully synthesized. The detail of the molecular structures of these NHC-Pd complexes was established by single-crystal X-ray diffraction studies. A chiral dimeric tridentate alkoxy/amidate/NHC palladium(II) complex effected oxidative Heck-type reactions of aryl boronic acids with acyclic alkenes at room temperature to afford the corresponding coupling products with high enantioselectivities.