Evaluation of time response of skin cells under artificial ischemia condition and a delay of pressure ulcer through an adjustment of physical environment

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Single-layered rabbit fibroblast-like cells in culture are insensitive to a reduction of oxygen and sensitive to the temperature due to the fact that a rate of detachment from the substrate decreases significantly for the cells in divalent cation free medium at 25 degrees centigrade compared to those at 37 degrees centigrade. Results from the finite element analysis for the soft tissues with microvessels near a bone prominence which is compressed onto a mattress show that the microvessels deform largely if the soft tissue is compressive over a long time scale and that an air support is valuable. To delay an occurrence of pressure ulcer, a prototype was created to support the soft tissues near a bone prominence by supplying the air with about 10 kPa to a polyethylene tube.