Coupled role of Nodal and Notch in the establishment of mesodermal tissue

在非洲爪哇胚胎发育的早期，结节信号在原肠胚的边缘区域诱导形成环状中胚层组织。为了了解决定中胚层面积的分子机制，研究了中胚层形成过程中的转录网络。许多实验表明，Nodal信号通过与Notch信号偶联来调节中胚层组织中边界的形成和细胞从生长到分化的相转变。

In early development of Xenopus embryo, Nodal signaling induces ring-shaped mesodermal tissue in the marginal zone of gastrula embryo. To understand the molecular mechanism determining the mesoderm area, transcriptional network was examined during the mesodermal formation. Several lines of experiments showed that Nodal signaling regulates the boundary formation and the cell phase transition from growth to differentiation in the mesodermal tissue by coupling with Notch signaling.