Pathophysiological roles of signal transductions between cholinergic nerves, interstitial cells and smooth muscle cells in overactive bladder.
Pathophysiological roles of signal transductions between cholinergic nerves, interstitial cells and smooth muscle cells in overactive bladder.
批准号:
20580322
负责人:
UNNO Toshihiro
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
In the present study, we attempted to clarify the phathogenetical mechanisms for the development of overactive bladder and investigated contractile responses of bladder smooth muscles to electrical field stimulation of intrinsic nerves in model mouse of overactive bladder. The results suggest that a component of bladder contraction responsible for unknown nerve stimulation was increased in the model mouse and that this unknown component may be a useful target for the new drugs for the treatment of overactive bladder.
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ハムスター小腸のタキキニン作動性神経-平滑筋間の情報伝達に対するNO作動性神経による抑制機構
NO能神经对仓鼠小肠速激神经与平滑肌信息传递的抑制机制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[谷合枝里子, 八舟宏典, 盛田怜子, 赤根弘敏, 林仁美, 鈴木和彦, 三森国敏, 渋谷淳, Iino S.他, 松山勇人他]
通讯作者:
松山勇人他
Nitrergic inhibition of tachykininergic neuro-muscular transmission vialcyclic GMP in the hamster ileum.
仓鼠回肠中快速激肽能神经肌肉传递的氮能抑制经由环 GMP。
DOI:
--
发表时间:
2011
期刊:
Journal of Veterinary Medical Science
影响因子:
1.2
作者:
[Matsuyama, H., Unno, T., Komori, S., Takewaki T.]
通讯作者:
Takewaki T.
Muscarinic receptor subtypes mediating Ca2+ sensitization of intestinal smooth muscle contraction; studies with mutant mice lacking the receptor subtypes.
毒蕈碱受体亚型介导肠道平滑肌收缩的 Ca2 敏感性;
DOI:
--
发表时间:
2010
期刊:
J.Vet.Med.Sci. 72
影响因子:
--
作者:
[Suguro, M., Matsuyama, H., Unno, T., Tanahashi, Y., Kitazawa, T., Yamada, M., Komori. S.]
通讯作者:
Komori. S.
DOI:
10.1111/j.1476-5381.2009.00475.x
发表时间:
2009-12-01
期刊:
BRITISH JOURNAL OF PHARMACOLOGY
影响因子:
7.3
作者:
[Tanahashi, Yasuyuki, Unno, Toshihiro, Komori, Seiichi]
通讯作者:
Komori, Seiichi
DOI:
10.2131/jts.35.795
发表时间:
2010-12-01
期刊:
JOURNAL OF TOXICOLOGICAL SCIENCES
影响因子:
2
作者:
[Fujikawa, Ryu, Muroi, Yoshikage, Ishir, Toshiaki]
通讯作者:
Ishir, Toshiaki
共 39 条
The roles of muscarinic receptor subtypes in the bladder contractions and the pathogenesis of overactive bladder
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批准号:17580253
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2005
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负责人:UNNO Toshihiro
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依托单位:
海外基金