Prediction of host specificity of morbillivirus based on the analysis of receptor in marine mammals

基于海洋哺乳动物受体分析预测麻疹病毒宿主特异性

• 批准号: 20580337
• 负责人: OHISHI Kauze
• 金额: $ 3万
• 依托单位: Japan Agency for Marine-Earth Science and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20580337/
• 关键词: モービリウイルス; 海棲哺乳類; 鯨類; レセプター; SLAM

Signaling lymphocyte activation molecule (SLAM) is a major cellular receptor for morbilliviruses. The complete nucleotide sequences of SLAM cDNA from five species of cetacean, pinniped and sirenian, were determined and the three-dimensional models were generated. We found some amino acid residues on the V domains of the SLAMs, which possibly affect the binding with the viral protein and host-virus specificity. The variation among cetacean species was found at 13 amino acid residue positions. The change of residues position at 68, 82, 90, and 130, were thought to affect the binding with virus.

信号淋巴细胞活化分子（SLAM）是麻疹病毒的主要细胞受体。测定了鳍足类和海牛类5种鲸类SLAM cDNA的全序列，并建立了三维模型。我们在SLAMs的V结构域上发现了一些氨基酸残基，这些氨基酸残基可能会影响SLAMs与病毒蛋白的结合和宿主病毒的特异性。在13个氨基酸残基位置上发现了鲸类物种间的差异。第68、82、90、130位残基位置的改变被认为影响了与病毒的结合。

项目成果

Host-virus specificity of morbilliviruses predicted by structural modeling of the marine mammal SLAM, a receptor

• DOI: 10.1016/j.cimid.2008.10.003
• 发表时间: 2010-05-01
• 期刊: COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
• 影响因子: 2
• 作者: Ohishi, Kazue;Ando, Akiko;Maruyama, Tadashi
• 通讯作者: Maruyama, Tadashi

Host-virus specificity of morbilliviruses predicted by structural modeling of the marine mammal SLAM

通过海洋哺乳动物 SLAM 的结构建模预测麻疹病毒的宿主病毒特异性

• 发表时间: 2010
• 期刊: a receptor. Comparative Immunology, Microbiology and Infectious Diseases 33
• 作者: Ohishi;K.;Ando;A.;et al.,(13名)
• 通讯作者: et al.,(13名)

Expression of signaling lymphocyte activation molecule(SLAM)and its sequence vanation m cetaceans.

鲸类中信号淋巴细胞激活分子(SLAM)的表达及其序列变化。

• 发表时间: 2010
• 作者: Shimizu;Y.;et al.
• 通讯作者: et al.

モーピリウイルスのレセプターSLAM分子の鯨類における結合部位のバリエーションと発現の解析

鲸类毛皮病毒受体SLAM分子结合位点变异及表达分析

• 发表时间: 2009
• 作者: Ohishi;K.;et al.;Ohishi K;清水優衣
• 通讯作者: 清水優衣

Host specificity based on a three-dimensional structure model of marine mammal signaling lymphocyte activation molecule (SLAM), a receptor of morbillivirus.

基于海洋哺乳动物信号淋巴细胞激活分子（SLAM）（麻疹病毒受体）三维结构模型的宿主特异性。

• 发表时间: 2008
• 作者: Ohishi;K.;et al.
• 通讯作者: et al.