Development and application of determination methods of salivary hormones for noninvasive diagnosis of endocrine disorders

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Saliva has recently been attracting attention as a noninvasive tool in clinical examinations. In this study, highly sensitive and specific liquid chromatography?electrospray ionization-tandem mass spectrometry methods were developed for the determination of low-molecular weight hormones and related compounds in saliva. For some compounds, novel derivatization procedures were developed to enhance their detection responses. The developed methods were useful in the diagnosis and treatment for several diseases and deficiencies, such as congenital adrenal hyperplasia, vitamin D deficiency, late-onset hypogonadism and Graves disease.