Development of a tailor-made molecular targeted oncologic diagnostic imaging using a newly-developed amino acid PET tracer.

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We developed and had a success of the radio-synthesis method of [18F]NMeFAMP and the results of the synthesis was quite excellent with yield evaluation about 20%, synthesis time about 90 min, radiochemical purity > 99.9%. However, we could not move ahead to quality control test, acute toxicity test, etc. On the other hand, we had successful results in the radio-synthesis methods of [18F]FACE using newly-introduced solid phase extraction techniques, two-pot distillation and one-pot distillation methods. With these techniques, we can provide [18F]FACE radio-synthesis methods with higher quality, cheaper, and more simple process, as compared to the traditional on-column hydrolysis method. After the approval of our ethical committee, we performed a human PET study with liver tumor patients using [18F]FACE and [18F]FDG, and the results were published by a well-known medical journal, Annals of Nuclear Medicine.