Biological Function of the M1 Family of Human Aminopeptidases
Biological Function of the M1 Family of Human Aminopeptidases
批准号:
20590057
负责人:
HATTORI Akira
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Adipocyte-derived leucine aminopeptidase, leukocyte-derived arginine aminopeptidase and Laeverin are belonging to the M1 family of zinc-metallo aminopeptidases. In this study, biochemical and cell biological analyses were conducted to comprehend their catalytic mechanisms and characteristic subcellular localization/tissue distribution (endoplasmic reticulum retention or placenta specific expression). Several amino acid residues essential for catalysis were identified and genetic/cell biological tools (reporter plasmids and cell lines) were also established.
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ヒト脂肪細胞由来ロイシンアミノペプチダーゼのGln-181残基は基質特異性に重要である
人脂肪细胞来源的亮氨酸氨基肽酶的 Gln-181 残基对于底物特异性很重要
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[後藤芳邦, 丹治弘江, 服部 明, 辻本雅文]
通讯作者:
辻本雅文
ERAP-1/A-LAP is secreted from macrophages treated with IFN- and LPS
ERAP-1/A-LAP 由用 IFN- 和 LPS 处理的巨噬细胞分泌
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Goto Y, Hattori A, Tsujimoto M]
通讯作者:
Tsujimoto M
Involvement of glutamine-238 in the substrate specificity of human laeverin/aminopeptidase Q.
谷氨酰胺 238 参与人 Laeverin/氨肽酶 Q 的底物特异性。
DOI:
--
发表时间:
2011
期刊:
Biol Pharm Bull. 34
影响因子:
--
作者:
[Goto Y, Yoshioka R, Arisaka N, Hattori A, Tsujimoto M.]
通讯作者:
Tsujimoto M.
小胞体アミノペプチダーゼの基質認識機構
内质网氨肽酶的底物识别机制
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[後藤芳邦, 丹治弘江, 服部 明, 辻本雅文]
通讯作者:
辻本雅文
The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: its effect in comparison with candesartan
重组氨肽酶A对自发性高血压大鼠高血压的影响:与坎地沙坦的比较
DOI:
--
发表时间:
2008
期刊:
Horm Metab Res. 40
影响因子:
--
作者:
[Ishii, M., Hattori, A., Numaguchi, Y., Tsujimoto, M., Ishiura, S., Kobayashi, H., Murohara, T., Wright, J.W. and Mizutani, S.]
通讯作者:
S.
共 24 条
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批准号:18K11994
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项目类别:Grant-in-Aid for Scientific Research (C)
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财政年份:2018
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依托单位:
Mechanism of unanchored polyubiquitin chain production
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依托单位:
Educational researches of in-service training for unskillful teachers after providing the Guideline in February 2008
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批准号:24531026
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.66万
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财政年份:2012
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负责人:HATTORI Akira
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依托单位:
Biochemical and physiological studies on deubiquitinating enzymes based on an analysis of the enzymatic activity dynamics
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批准号:23310160
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.81万
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财政年份:2011
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依托单位:
Study on a new release mechanism abnormality (unresponsiveness to thromboxane A_2) of platelet
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批准号:61480257
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资助金额:$2.3万
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财政年份:1986
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负责人:HATTORI Akira
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依托单位: