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Biological Function of the M1 Family of Human Aminopeptidases

Biological Function of the M1 Family of Human Aminopeptidases
人类氨肽酶 M1 家族的生物学功能
批准号:
20590057
负责人:
HATTORI Akira
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

HATTORI Akira的其他基金

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中文摘要
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英文摘要
Adipocyte-derived leucine aminopeptidase, leukocyte-derived arginine aminopeptidase and Laeverin are belonging to the M1 family of zinc-metallo aminopeptidases. In this study, biochemical and cell biological analyses were conducted to comprehend their catalytic mechanisms and characteristic subcellular localization/tissue distribution (endoplasmic reticulum retention or placenta specific expression). Several amino acid residues essential for catalysis were identified and genetic/cell biological tools (reporter plasmids and cell lines) were also established.
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会议论文
ヒト脂肪細胞由来ロイシンアミノペプチダーゼのGln-181残基は基質特異性に重要である
人脂肪细胞来源的亮氨酸氨基肽酶的 Gln-181 残基对于底物特异性很重要
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [後藤芳邦, 丹治弘江, 服部 明, 辻本雅文]
通讯作者: 辻本雅文
ERAP-1/A-LAP is secreted from macrophages treated with IFN- and LPS
ERAP-1/A-LAP 由用 IFN- 和 LPS 处理的巨噬细胞分泌
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Goto Y, Hattori A, Tsujimoto M]
通讯作者: Tsujimoto M
Involvement of glutamine-238 in the substrate specificity of human laeverin/aminopeptidase Q.
谷氨酰胺 238 参与人 Laeverin/氨肽酶 Q 的底物特异性。
DOI: --
发表时间: 2011
期刊: Biol Pharm Bull. 34
影响因子: --
作者: [Goto Y, Yoshioka R, Arisaka N, Hattori A, Tsujimoto M.]
通讯作者: Tsujimoto M.
小胞体アミノペプチダーゼの基質認識機構
内质网氨肽酶的底物识别机制
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [後藤芳邦, 丹治弘江, 服部 明, 辻本雅文]
通讯作者: 辻本雅文
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      2012
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