Role of lymphocytic cholinergic system in regulation of fat metabolism
Role of lymphocytic cholinergic system in regulation of fat metabolism
批准号:
20590096
负责人:
FUJII Takeshi
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We investigated the involvement of non-neuronal cholinergic system in lymphocytes in fat metabolism. Acetylcholine (ACh) production, activity and mRNA expression of choline acetyltransferase (ChAT), an ACh-synthesizing enzyme, in ob/ob mice, an animal model of type 2 obese diabetes, is reduced when compared with that of control (lean) mice. Lymphocytic cholinergic activity increased with age. These findings suggest that lymphocytic cholinergic system is involved in regulation of fat metabolism.
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Acetylcholine synthesis and release in NIH3T3 cells co-expressing the high-affinity choline transporter and choline acetyltransferasae.
共表达高亲和力胆碱转运蛋白和胆碱乙酰转移酶的 NIH3T3 细胞中乙酰胆碱的合成和释放。
DOI:
--
发表时间:
2009
期刊:
Journal of Neuroscience Research. 87
影响因子:
--
作者:
[Fujii T, Masai M, Misawa H, Okuda T, Takada-Takatori Y, Moriwaki Y, Haga T, Kawashima K.]
通讯作者:
Kawashima K.
SLURP-1によるTリンパ球からのアセチルコリン遊離促進
SLURP-1 促进 T 淋巴细胞释放乙酰胆碱
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[藤井健志, 高鳥悠記, 川島紘一郎]
通讯作者:
川島紘一郎
メディエートフォアを介するT細胞からのアセチルコリン遊離機構
T 细胞通过介质释放乙酰胆碱的机制
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[藤井健志, 高鳥悠記, 川島紘一郎]
通讯作者:
川島紘一郎
免疫機能とムスカリン受容体
免疫功能和毒蕈碱受体
DOI:
--
发表时间:
2011
期刊:
鼻アレルギーフロンティア 11
影响因子:
--
作者:
[藤井健志, 高鳥悠記]
通讯作者:
高鳥悠記
SLURP-1によるTリンパ球からのアセチルコリンの遊離促進
SLURP-1 促进 T 淋巴细胞释放乙酰胆碱
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[藤井 健志]
通讯作者:
藤井 健志
共 8 条
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负责人:FUJII Takeshi
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海外基金