Study on the control of gene expression network in Streptomyces growing in the soil environment

点击翻译按钮获取中文摘要

To provide new insights into the cellular response to nutrients and regulation cascade of antibiotic production genes in global gene expression of Streptomyces in soil, genome-wide transcriptional analysis with microarray technology was performed using RNA extracted from the wild type and mutant strains of Streptomyces coelicolor grown in soil cultures. Microarray analyses revealed that expression of genes for secondary metabolism was induced by chitin together with primary metabolic genes in soil cultures of Streptomyces coelicolor. The data also indicated that a transcriptional factor, DasR, was involved in the regulation of gene expression for chitin catabolism, secondary metabolism and stress responses.