Interaction of pathogenic Rhodococcus equi with mammalian macrophages

致病性马红球菌与哺乳动物巨噬细胞的相互作用

• 批准号: 5373507
• 负责人: Professor Dr. Albert Haas
• 金额: --
• 依托单位: Institut für Zellbiologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2002
• 资助国家: 德国
• 起止时间: 2001-12-31 至 2008-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5373507?language=en
• 关键词: Interaction; pathogenic; Rhodococcus; equi; mammalian

When microorganisms enter the sterile section of our body (e.g., after trauma), they readily encounter professional phagocytic cells (in particular, neutrophils and macrophages) which ingest and kill the microbes. Some intracellular pathogens, however, escape this host defense mechanism and can even multiply in phagocytic host cells. These microorganisms include members of the species Rhodococcus equi which are found in macrophage phagosomes that do not mature to phagolysosomes, and which can destroy their host cells in a matter of hours to days. These two unusual features are uniquely regulated by the presence of a plasmid which is essential for virulence of R. equi in mice and horses. The proposed studies will contribute to an understanding at the molecular level of how Rhodococcus-containing phagosomes are compartmentalized during an infection, how the bacteria can destroy their host cells and to what extent intracellular compartmentalization determines host cell destruction.

当微生物进入我们身体的无菌部分时（例如，在创伤后），它们容易遇到吞噬并杀死微生物的专职吞噬细胞（特别是嗜中性粒细胞和巨噬细胞）。然而，一些细胞内病原体逃避这种宿主防御机制，甚至可以在吞噬宿主细胞中繁殖。这些微生物包括马红球菌（Rhodococcus equi）物种的成员，马红球菌存在于不成熟为吞噬溶酶体的巨噬细胞吞噬体中，并且可以在数小时至数天内破坏其宿主细胞。这两个不寻常的特征是由一个质粒的存在，这是必不可少的毒力的R。在老鼠和马中的马。拟议的研究将有助于在分子水平上了解红球菌的吞噬体在感染过程中是如何划分的，细菌如何破坏宿主细胞，以及细胞内划分在多大程度上决定宿主细胞的破坏。