Developments of cerebral sulci and gyri in cynomolgus monkey fetuses : a quantitative analysis using 7 tesla MRI

采用高空间分辨率7-特斯拉磁共振成像系统，对胚胎日（EDs） 70 ~ 150日经福尔马林固定的食猴胎儿的大脑进行t1加权MRI成像。结果阐明了基于mri的这种灵长类动物脑沟和脑回出现的年表。定量分析显示初级脑沟的出现与皮层下白质束的发育有关。此外，弥散张量成像揭示了每个初级脑沟与特定皮质-皮质长联合纤维的时空关系。

T1-weighted MRI images were acquired from formalin-fixed cerebra of cynomolgus monkey fetuses on embryonic days (EDs) 70 to 150 using a high spatial resolution 7-tesla MR system. The results clarified MRI-based chronology of the emergences of cerebral sulci and gyri in this primate. Quantitative analysis revealed a correlation of the emergence of the primary sulci with the development of subcortical white matter bundles. Furthermore, diffusion tensor imaging revealed a spatiotemporal relation of each primary sulci with the specific cortico-cortical long associative fibers.