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Identification of novel acceptor proteins for polyADP-ribosylation, determination of the site of modification and clarification of biological function

Identification of novel acceptor proteins for polyADP-ribosylation, determination of the site of modification and clarification of biological function
聚 ADP 核糖基化新型受体蛋白的鉴定、修饰位点的确定以及生物学功能的阐明
批准号:
20590291
负责人:
MIWA Masanao
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
PolyADP-ribosylation is a posttranslational modification that is involved in various cellular events including cell growth and cell death. We are trying to clarify the function of polyADP-ribosylation using Drosophila as an animal model for future application to analyze the mechanism of neurological diseases. We found 9-14 new acceptor proteins of polyADP-ribosylation using 2-D gel electrophoresis and now trying to identify those new proteins by mass spectroscopy.
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会议论文
Separation and identification of poly(ADP-ribosyl)ated acceptor proteins in PARG-knockout Drosophila melanogaster that shows neuronal cell death
PARG 敲除黑腹果蝇中显示神经元细胞死亡的聚 (ADP-核糖基) 化受体蛋白的分离和鉴定
DOI: --
发表时间: 2010
期刊:
影响因子: --
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DNA損傷で誘導される中心体増幅の新しいシグナル経路
DNA损伤诱导中心体扩增的新信号通路
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [三輪正直, 他]
通讯作者:
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [黒田泰仁, 他]
通讯作者:
PARPのポリADP-リボシル化を受ける修飾部位の特定
PARP 中进行聚 ADP 核糖基化的修饰位点的鉴定
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [森田寛之, 他]
通讯作者:
34
    Identification of acceptor proteins and their modification sites of polyADP-ribosylation and biological function
    Molecular oncological and epidemiological study on initiation and progression of human biliary tract cancer in Asia
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    Genetic oncological and molecular epidemiological research ondevelopment and progression of human bile duct cancer in Asia
    海外基金