Identification of novel acceptor proteins for polyADP-ribosylation, determination of the site of modification and clarification of biological function
Identification of novel acceptor proteins for polyADP-ribosylation, determination of the site of modification and clarification of biological function
批准号:
20590291
负责人:
MIWA Masanao
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
PolyADP-ribosylation is a posttranslational modification that is involved in various cellular events including cell growth and cell death. We are trying to clarify the function of polyADP-ribosylation using Drosophila as an animal model for future application to analyze the mechanism of neurological diseases. We found 9-14 new acceptor proteins of polyADP-ribosylation using 2-D gel electrophoresis and now trying to identify those new proteins by mass spectroscopy.
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Separation and identification of poly(ADP-ribosyl)ated acceptor proteins in PARG-knockout Drosophila melanogaster that shows neuronal cell death
PARG 敲除黑腹果蝇中显示神经元细胞死亡的聚 (ADP-核糖基) 化受体蛋白的分离和鉴定
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[野殿弘人, 他]
通讯作者:
他
DNA損傷で誘導される中心体増幅の新しいシグナル経路
DNA损伤诱导中心体扩增的新信号通路
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[三輪正直, 他]
通讯作者:
他
PARGノックアウトショウジョウバエにおけるポリADP-リボース蓄積の発生に与える影響
对 PARG 敲除果蝇中聚 ADP 核糖积累发育的影响
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[黒田泰仁, 他]
通讯作者:
他
PARPのポリADP-リボシル化を受ける修飾部位の特定
PARP 中进行聚 ADP 核糖基化的修饰位点的鉴定
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[森田寛之, 他]
通讯作者:
他
Approaches to separate and identify polyADP-ribosylated proteins using PARG knockout Drosophila.
使用 PARG 敲除果蝇分离和鉴定聚 ADP 核糖基化蛋白的方法。
DOI:
--
发表时间:
2011
期刊:
Methods in Molecular Biology on Poly(ADP-ribose)(A.Tulin ed., Humana Press Inc., Totowa, NJ, USA) in press
影响因子:
--
作者:
[Nodono, H., Hamada, A., Kuroda, Y., Hasegawa, M., Kondo, C., Che, F.S., Hanai, S., Miwa, M.]
通讯作者:
M.
共 34 条
Identification of acceptor proteins and their modification sites of polyADP-ribosylation and biological function
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批准号:23590350
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
-
财政年份:2011
-
负责人:MIWA Masanao
-
依托单位:
Molecular oncological and epidemiological study on initiation and progression of human biliary tract cancer in Asia
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批准号:21406011
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.24万
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财政年份:2009
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负责人:MIWA Masanao
-
依托单位:
DETERMINATION OF UNKNOWN POLY(ADP-RIBOSYL)ATED PROTEINS AND BINDING SITES
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批准号:18590277
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
-
财政年份:2006
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负责人:MIWA Masanao
-
依托单位:
Genetic oncological and molecular epidemiological research ondevelopment and progression of human bile duct cancer in Asia
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批准号:18406005
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.15万
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财政年份:2006
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负责人:MIWA Masanao
-
依托单位:
Determination of unknown poly(ADP-ribosyl)ated proteins and binding sites
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批准号:16390072
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.94万
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财政年份:2004
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负责人:MIWA Masanao
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依托单位:
Genetic oncological and molecular epidemiological research on development and progression of human bile duct cancer in Asia
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批准号:15406008
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.14万
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财政年份:2003
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负责人:MIWA Masanao
-
依托单位:
Analysis of infection, integration and tumorigenesis of HTLV-1
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批准号:14570260
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2002
-
负责人:MIWA Masanao
-
依托单位:
Analysis of infection, integration and tumorigenesis of HTLV-1
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批准号:12670272
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:2000
-
负责人:MIWA Masanao
-
依托单位:
Genetic oncological and molecular epidemiological research on development and progression of the biliary tract cancer in Asia
-
批准号:12576002
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$6.59万
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财政年份:2000
-
负责人:MIWA Masanao
-
依托单位:
Free Transmission of Human T-cell Leukemia Virus Type 1 to Mouse Cells
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批准号:10670280
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
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财政年份:1998
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负责人:MIWA Masanao
-
依托单位:
Change of GTP-binding Protein in Hormone Producing Tumors of Rats
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批准号:03670118
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1991
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负责人:MIWA Masanao
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依托单位:
海外基金