Analyses of DNA methylation and histone methylation changes in human malignancies
Analyses of DNA methylation and histone methylation changes in human malignancies
批准号:
20590325
负责人:
KONDO Yutaka
金额:
$2.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
In the current study, to clarify the contribution of epigenetic abnormalities to the human tumorigenesis, we conducted high-throughput analysis of DNA methylation, lysine 27 trimethylation and genetic alterations in human malignancies. Using malignant mesothelioma as a model, we demonstrated a characteristic epigenetic profile of human mesothelioma and uncover multiple distinct epigenetic abnormalities that lead to the silencing of tumor-suppressor genes in mesothelioma and could serve as diagnostic or prognostic targets.
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DOI:
10.1016/j.canlet.2009.04.020
发表时间:
2009-10-18
期刊:
CANCER LETTERS
影响因子:
9.7
作者:
[Yuki, Kanako, Natsume, Atsushi, Wakabayashi, Toshihiko]
通讯作者:
Wakabayashi, Toshihiko
「At the Front of Epigenetic Research」Cross-talk of DNA methylation and histone methylation in human cancers.
“表观遗传学研究的前沿”人类癌症中 DNA 甲基化和组蛋白甲基化的交叉对话。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kondo Y]
通讯作者:
Kondo Y
Yonsei Medical Journal 「Epigenetic cross-talk between DNA methylation anc histone modifications in human cancers」
延世医学杂志“人类癌症中 DNA 甲基化和组蛋白修饰之间的表观遗传串扰”
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Suzuki H, Toyota M, Kondo Y, Shinomura Y. Humana Press, Kondo Y., 岡本泰幸, Yutaka Kondo]
通讯作者:
Yutaka Kondo
DOI:
10.1093/carcin/bgn170
发表时间:
2008-10-01
期刊:
CARCINOGENESIS
影响因子:
4.7
作者:
[Gao, Wentao, Kondo, Yutaka, Sekido, Yoshitaka]
通讯作者:
Sekido, Yoshitaka
「Epigenetics in Development and Disease Conference」Role of histone H3 lysine 27 tri-methylation in human brain tumor-propagating cells.
“发育和疾病会议中的表观遗传学”组蛋白 H3 赖氨酸 27 三甲基化在人脑肿瘤增殖细胞中的作用。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ishii H., Saito T., Kondo Y]
通讯作者:
Kondo Y
共 36 条
Study of regulatory mechanism controlling cancer cell reprogramming
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批准号:25290048
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.98万
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财政年份:2013
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负责人:KONDO Yutaka
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依托单位:
Integrated studies of aerosol-cloud-precipitation system in Asia based on measurement and model calculations
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批准号:23221001
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$137.7万
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财政年份:2011
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负责人:KONDO Yutaka
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依托单位:
Epigenetic plasticity as a novel target for cancer treatment
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批准号:22300344
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.15万
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财政年份:2010
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负责人:KONDO Yutaka
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依托单位:
Studies of impacts of black carbon aerosol on climate based on aircraft observations
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批准号:19101001
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$70.8万
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财政年份:2007
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负责人:KONDO Yutaka
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依托单位:
Roles of Histone Methyltransferase in Human Cancer
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批准号:18590393
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.55万
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财政年份:2006
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负责人:KONDO Yutaka
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依托单位:
Studies on physical-chemical processes of aerosol-cloud interaction
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批准号:17201003
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$32.7万
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财政年份:2005
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负责人:KONDO Yutaka
-
依托单位:
Studies on strategic control of photochemical oxidants in mega-cities
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批准号:14208061
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项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$33.61万
-
财政年份:2002
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负责人:KONDO Yutaka
-
依托单位:
Development of airborne instrument for CO measurement
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批准号:12358009
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$19.27万
-
财政年份:2000
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负责人:KONDO Yutaka
-
依托单位:
Tropospheric photochemistry and ozone budget
-
批准号:10144210
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas (A)
-
资助金额:$83.97万
-
财政年份:1998
-
负责人:KONDO Yutaka
-
依托单位:
Tropospheric ozone chemistry over the tropical Pacific
-
批准号:09041105
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$9.86万
-
财政年份:1997
-
负责人:KONDO Yutaka
-
依托单位:
Development of mass spectroscopic technique for nitric acid measurements
-
批准号:09358012
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$16.38万
-
财政年份:1997
-
负责人:KONDO Yutaka
-
依托单位:
Chemistry of tropospheric ozone over the tropical Pacific
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批准号:08041106
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$5.63万
-
财政年份:1996
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负责人:KONDO Yutaka
-
依托单位:
A Study of Chemical Processes Leading to Ozone Losses in the Midlatitude Stratosphere
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批准号:06402017
-
项目类别:Grant-in-Aid for General Scientific Research (A)
-
资助金额:$9.28万
-
财政年份:1994
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负责人:KONDO Yutaka
-
依托单位:
Chemistry of Stratospheric Ozone in the Arctic
-
批准号:06041050
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$8.0万
-
财政年份:1994
-
负责人:KONDO Yutaka
-
依托单位:
Joint Research on the Chemistry of Stratospheric Ozone Loss
-
批准号:05044218
-
项目类别:Grant-in-Aid for Overseas Scientific Survey.
-
资助金额:$0.0万
-
财政年份:1993
-
负责人:KONDO Yutaka
-
依托单位:
Development of spectroscopic system for the measurements of stratospheric OClO and BrO
-
批准号:04554015
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
-
资助金额:$4.03万
-
财政年份:1992
-
负责人:KONDO Yutaka
-
依托单位:
A Study of Technique for the Measurement of Total Reactive Nitrogen in the Troposphere
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批准号:03452062
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$2.56万
-
财政年份:1991
-
负责人:KONDO Yutaka
-
依托单位:
DEVELOPMENT OF THE METHOD TO MEASURE TOTAL REACTIVE NITROGEN IN THE MIDDLE ATMOSPHERE
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批准号:63540319
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.02万
-
财政年份:1988
-
负责人:KONDO Yutaka
-
依托单位:
海外基金