Analysis for carcinogenesis of lung cancer in idiopathic pulmonary fibrosis by inflammation and precancerous change

特发性肺纤维化中炎症及癌前病变对肺癌的致癌作用分析

• 批准号: 20590336
• 负责人: OTA Satoshi
• 金额: $ 3.08万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590336/
• 关键词: 肺がん; 肺癌; 炎症; 前癌状態; 特発性肺線維症

Idiopathic pulmonary fibrosis is the interstitial pneumonia of unknown cause and refractory lesion, with a high risk for lung cancer. To study the difference of squamous cell carcinoma with or without idiopathic pulmonary fibrosis, the transcriptome expression level of each squamous cell carcinoma sample were compared. Famous oncogene MYCN, cytoskeleton protein MYH11, unknown function protein ARMC4 were upregulated. One of downregulated protein was MTSS-1 which supposed to be the role as disassembling the actin fibers.

特发性肺纤维化是一种病因不明、病变难治的间质性肺炎，具有较高的肺癌发病风险。为了研究有无特发性肺纤维化的鳞癌的差异，比较了每个鳞癌标本的转录组表达水平。著名癌基因MYCN、细胞骨架蛋白MYH11、未知功能蛋白ARMC4表达上调。下调的蛋白质之一是mTSS-1，它被认为具有分解肌动蛋白纤维的作用。

项目成果

AKR1B10 in usual interstitial pneumonia: Expression in squamous metaplasia in association with smoking and lung cancer

• DOI: 10.1016/j.prp.2006.12.012
• 发表时间: 2008-01-01
• 期刊: PATHOLOGY RESEARCH AND PRACTICE
• 影响因子: 2.8
• 作者: Li, Chih-Ping;Goto, Akiteru;Fukayama, Masashi
• 通讯作者: Fukayama, Masashi

Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches

• DOI: 10.1002/ijc.24947
• 发表时间: 2010-04-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Kusakabe, Masashi;Kutomi, Tomoko;Takai, Daiya
• 通讯作者: Takai, Daiya