Investigation of disease-specific MMP to conquer acute coronary syndrome ?study with transgenic rabbit
Investigation of disease-specific MMP to conquer acute coronary syndrome ?study with transgenic rabbit
批准号:
20590343
负责人:
WATANABE Teruo
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We established MMP-1 and MMP-9 transgenic rabbits, which express the enzymes in their macrophages. MMP-9 Tg rabbits have granuloma-like lesionin their toes. Female MMP-9 and MMP-12 Tg rabbits were mated with WHHL MI, and hybrid offsprings were obtained.
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動脈硬化の発生におけるC反応性蛋白の役割:遺伝子改変ウサギ・モデルによる解析
C反应蛋白在动脉粥样硬化发展中的作用:使用转基因兔模型进行分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Nakano H, Funasaka T, Hashizume C, Wong RW^*, 範江林]
通讯作者:
範江林
ホームページ等。
主页等
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.1161/atvbaha.109.190264
发表时间:
2009-12-01
期刊:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
影响因子:
8.7
作者:
[Koike, Tomonari, Kitajima, Shuji, Fan, Jianglin]
通讯作者:
Fan, Jianglin
DOI:
10.14670/hh-23.1503
发表时间:
2008-12
期刊:
Histology and histopathology
影响因子:
2
作者:
[Ying Yu;T. Koike;S. Kitajima;Enqi Liu;M. Morimoto;M. Shiomi;K. Hatakeyama;Y. Asada;Ke-Yong Wang;Y. Sasaguri;Teruo Watanabe;Jianglin Fan]
通讯作者:
Ying Yu;T. Koike;S. Kitajima;Enqi Liu;M. Morimoto;M. Shiomi;K. Hatakeyama;Y. Asada;Ke-Yong Wang;Y. Sasaguri;Teruo Watanabe;Jianglin Fan
Transgenic Rabbits Expressing Human C-reactive Protein.
表达人类 C 反应蛋白的转基因兔。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Koike T, et al.]
通讯作者:
et al.
共 10 条
Effects of MMP-9 on plaque rupture: development of a novel model for acute coronary syndromes.
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批准号:23590401
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
-
财政年份:2011
-
负责人:WATANABE Teruo
-
依托单位:
Elucidation of MMP-12 functions in atherosclerosis using transgenic rabbit models
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批准号:13470046
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.68万
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财政年份:2001
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负责人:WATANABE Teruo
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依托单位:
DEVELOPMENT OF CLONE TRANSGENIC RABBITS FOR THE STUDY OF ATHEROSCLEROSIS
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批准号:11557016
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.51万
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财政年份:1999
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负责人:WATANABE Teruo
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依托单位:
Role of apo (a) in atherogenesis. A study using transgenic rabbits expressing human apo (a)
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批准号:10470046
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.19万
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财政年份:1998
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负责人:WATANABE Teruo
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依托单位:
Reconstruction of Early Paleozoic arc-trench system: a case study in the eastern Gondwana margin
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批准号:10041102
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项目类别:Grant-in-Aid for Scientific Research (A).
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资助金额:$7.23万
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财政年份:1998
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负责人:WATANABE Teruo
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依托单位:
Development of transgenic rabbits as models for atherosclerotic research
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批准号:08557017
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$9.28万
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财政年份:1996
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负责人:WATANABE Teruo
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依托单位:
Studies on Immunobiological Mechanisms in Atherogenesis
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批准号:07457047
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.67万
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财政年份:1995
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负责人:WATANABE Teruo
-
依托单位:
Development of a 3- dimensional culture model system simulating arterial intima and its application for atherosclerosis study.
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批准号:05557016
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$4.48万
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财政年份:1993
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负责人:WATANABE Teruo
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依托单位:
Reconstruction of pre-breakup Paleozoic-suture of Gondowana continent in Australia
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批准号:04041012
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项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$8.96万
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财政年份:1992
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负责人:WATANABE Teruo
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依托单位:
Role of Macrophages and Immune Cells in Atherogenesis
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批准号:04454181
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.58万
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财政年份:1992
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负责人:WATANABE Teruo
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依托单位:
CONSIDERATION ON THE RELATION BETWEEN DUCTILE FLOW AND MOTAMORPHIC REACTIONS IN THE HIGH PRESSURE MOTAMORPHIC BELTS.
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批准号:01470054
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.78万
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财政年份:1989
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负责人:WATANABE Teruo
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依托单位:
Role of Macrophages in Atherogenesis
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批准号:63570144
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1988
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负责人:WATANABE Teruo
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依托单位:
PETROLOGICAL STUDY CONCERNING ORIGIN OF PELITIC SCHISTS IN THE SANBAGAWA BELT
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批准号:61540592
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.54万
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财政年份:1986
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负责人:WATANABE Teruo
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依托单位:
海外基金