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Effects of MMP-9 on plaque rupture: development of a novel model for acute coronary syndromes.

Effects of MMP-9 on plaque rupture: development of a novel model for acute coronary syndromes.
MMP-9 对斑块破裂的影响:急性冠脉综合征新型模型的开发。
批准号:
23590401
负责人:
WATANABE Teruo
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
翻译
分析基质金属蛋白酶(MMP)-9转基因(Tg)兔以阐明MMP-9在动脉粥样硬化中的作用。高胆固醇饮食负荷时,MMP-9 Tg组动脉病变较对照组大。随后,将MMP-9 Tg兔与MMP-12(已知加速动脉粥样硬化的起始)Tg兔交配,并建立MMP-9/12 Tg兔作为急性冠状动脉综合征的新模型的候选者。
英文摘要
Matrix metalloprotease (MMP)-9 transgenic (Tg) rabbits were analyzed to clarify the effects of MMP-9 on atherosclerosis. With high cholesterol diet loading, the arteriosclerotic lesion in MMP-9 Tg rabbit was larger than in control rabbit. Subsequently, MMP-9 Tg rabbit was mated with MMP-12 (known to accelerate the initiation of atherosclerosis) Tg rabbit and MMP-9/12 Tg rabbit was established as a candidate for a novel model for acute coronary syndromes.
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DOI: 10.1089/ars.2012.4549
发表时间: 2012-11-01
期刊: ANTIOXIDANTS & REDOX SIGNALING
影响因子: 6.6
作者: [Guo, Xin, Yamada, Sohsuke, Sasaguri, Yasuyuki]
通讯作者: Sasaguri, Yasuyuki
DOI: 10.1161/atvbaha.112.300445
发表时间: 2013-02
期刊: Arteriosclerosis, thrombosis, and vascular biology
影响因子: --
作者: [Wang Y, Niimi M, Nishijima K, Waqar AB, Yu Y, Koike T, Kitajima S, Liu E, Inoue T, Kohashi M, Keyamura Y, Yoshikawa T, Zhang J, Ma L, Zha X, Watanabe T, Asada Y, Chen YE, Fan J]
通讯作者: Fan J
DOI: 10.1089/ars.2012.4946
发表时间: 2013-12-10
期刊: ANTIOXIDANTS & REDOX SIGNALING
影响因子: 6.6
作者: [Nabeshima, Atsunori, Yamada, Sohsuke, Sasaguri, Yasuyuki]
通讯作者: Sasaguri, Yasuyuki
Investigation of disease-specific MMP to conquer acute coronary syndrome ?study with transgenic rabbit
  • 批准号:
    20590343
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.08万
  • 财政年份:
    2008
  • 负责人:
    WATANABE Teruo
  • 依托单位:
Elucidation of MMP-12 functions in atherosclerosis using transgenic rabbit models
  • 批准号:
    13470046
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $7.68万
  • 财政年份:
    2001
  • 负责人:
    WATANABE Teruo
  • 依托单位:
DEVELOPMENT OF CLONE TRANSGENIC RABBITS FOR THE STUDY OF ATHEROSCLEROSIS
Role of apo (a) in atherogenesis. A study using transgenic rabbits expressing human apo (a)
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