Effects of MMP-9 on plaque rupture: development of a novel model for acute coronary syndromes.

MMP-9 对斑块破裂的影响：急性冠脉综合征新型模型的开发。

• 批准号: 23590401
• 负责人: WATANABE Teruo
• 金额: $ 3.33万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590401/
• 关键词: MMP-9; 動脈硬化; 遺伝子組換え; ウサギ; 病態モデル

Matrix metalloprotease (MMP)-9 transgenic (Tg) rabbits were analyzed to clarify the effects of MMP-9 on atherosclerosis. With high cholesterol diet loading, the arteriosclerotic lesion in MMP-9 Tg rabbit was larger than in control rabbit. Subsequently, MMP-9 Tg rabbit was mated with MMP-12 (known to accelerate the initiation of atherosclerosis) Tg rabbit and MMP-9/12 Tg rabbit was established as a candidate for a novel model for acute coronary syndromes.

为了阐明基质金属蛋白酶-9在动脉粥样硬化中的作用，对基质金属蛋白酶-9转基因兔进行了检测。在高胆固醇饮食负荷下，MMP9TG组兔动脉粥样硬化病变明显大于对照组。随后，将已知的加速动脉粥样硬化形成的基质金属蛋白酶-9与基质金属蛋白酶-12交配，建立了一种新的急性冠脉综合征模型。

项目成果

Overexpression of Peroxiredoxin 4 Attenuates Atherosclerosis in Apolipoprotein E Knockout Mice

• DOI: 10.1089/ars.2012.4549
• 发表时间: 2012-11-01
• 期刊: ANTIOXIDANTS & REDOX SIGNALING
• 影响因子: 6.6
• 作者: Guo, Xin;Yamada, Sohsuke;Sasaguri, Yasuyuki
• 通讯作者: Sasaguri, Yasuyuki

Human apolipoprotein A-II protects against diet-induced atherosclerosis in transgenic rabbits.

• DOI: 10.1161/atvbaha.112.300445
• 发表时间: 2013-02
• 期刊: Arteriosclerosis, thrombosis, and vascular biology
• 作者: Wang Y;Niimi M;Nishijima K;Waqar AB;Yu Y;Koike T;Kitajima S;Liu E;Inoue T;Kohashi M;Keyamura Y;Yoshikawa T;Zhang J;Ma L;Zha X;Watanabe T;Asada Y;Chen YE;Fan J
• 通讯作者: Fan J

Peroxiredoxin 4 Protects Against Nonalcoholic Steatohepatitis and Type 2 Diabetes in a Nongenetic Mouse Model

• DOI: 10.1089/ars.2012.4946
• 发表时间: 2013-12-10
• 期刊: ANTIOXIDANTS & REDOX SIGNALING
• 影响因子: 6.6
• 作者: Nabeshima, Atsunori;Yamada, Sohsuke;Sasaguri, Yasuyuki
• 通讯作者: Sasaguri, Yasuyuki