Pathological examination about the effects of angiogenic factors on the exacerbation and the improvement of vascular lesions

动脉粥样硬化性疾病是一个需要预防的重大公共卫生问题。动脉粥样硬化与死亡风险增加有关，特别是在冠心病和慢性肾脏病(CKD)中。我们从血管生成因子入手，对动脉粥样硬化的发病机制进行了探讨。我们发现，血管内皮生长因子-A和血管内皮生长因子-C促进了载脂蛋白E-KO小鼠动脉粥样硬化病变的发展。我们还发现慢性肾脏病与慢性炎症加速引起的冠心病风险增加有关。

Atherosclerotic diseases are a significant public health problem to prevent. Atherosclerosis is associated with an increased risk of death, especially in coronary heart disease and chronic kidney disease (CKD). We investigated the mechanisms of atherosclerosis proceeded with the focus on angiogenic factors. We revealed that VEGF-A and VEGF-C progressed atherosclerotic lesions of ApoE-KO mice. We also revealed that CKD was associated with an increased risk of coronary heart disease caused by the acceleration of chronic inflammation.