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Influence of depression and mental stress on the experimental atherogenesis in mice

抑郁和精神应激对小鼠实验性动脉粥样硬化形成的影响

基本信息

批准号：
20590404
负责人：
KATO Seiya
金额：
$ 3.08万
依托单位：
University of the Ryukyus
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2010
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590404/
关键词：
動脈硬化疾患モデル動物うつストレス免疫炎症行動学動物

项目摘要

Various risk factors have been shown to be involved in human atherogenesis and onset of cardiovascular diseases. Epidemiological studies have revealed that depression and mental stress increase in the risks of cardiovascular diseases. However, cellular and molecular aspects regarding how depression and mental stress influence on the disease process, have not been fully investigated. In the present study, we tested the effect of psychological stress on atheogenesis using the experimental mouse model. Aged ApoE knockout mice were fed with high fat diet (HFD32) inducing obesity and insulin resistance, with or without adding the forced swimming test. Stress-overloaded group represented an increase in serum cortisol level and changes in cytokine (Th1/Th2) balance of the Con-A stimulated splenic cells. Thus psychological stress may influence on the alteration of some humoral factors that have been suggested their involvement in the atherosclerotic processes. However, no histological differences were observed on the degree of atherosclerotic area and plaque stability index, suggesting that complex factors would be involved in the atherogenetic process of the stress-suffered individuals.

各种危险因素已被证明参与人类动脉粥样硬化形成和心血管疾病的发病。流行病学研究表明，抑郁和精神压力增加了心血管疾病的风险。然而，关于抑郁症和精神压力如何影响疾病过程的细胞和分子方面尚未得到充分研究。在本研究中，我们使用实验小鼠模型测试心理应激对动脉粥样硬化发生的影响。用高脂饮食（HFD 32）喂养老年ApoE基因敲除小鼠，诱导肥胖和胰岛素抵抗，加入或不加入强迫游泳试验。应激超负荷组血清皮质醇水平升高，Con-A刺激后脾细胞Th 1/Th 2细胞因子平衡改变。因此，心理应激可能会影响某些体液因子的变化，这些体液因子被认为参与了动脉粥样硬化的过程。但在动脉粥样硬化面积和斑块稳定性指数方面无组织学差异，提示应激个体的动脉粥样硬化发生过程可能涉及复杂的因素。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Lysophosphatidic acid differentially modulaes vascular smooth muscle phenotype.

溶血磷脂酸差异调节血管平滑肌表型。

DOI：
发表时间：
2009
期刊：
影响因子：
0
作者：
Matafolau HT;Matsubara H;Arakaki K;Kinjo T;Kato S.
通讯作者：
Kato S.

Endogenous and Exogenous Thioredoxin 1 Prevents Goblet Cell Hyperplasia in a Chronic Antigen Exposure Asthma Model

DOI：
10.2332/allergolint.09-oa-0086
发表时间：
2009-09-01
期刊：
Allergology International
影响因子：
6.8
作者：
Imaoka, Haruki;Hoshino, Tomoaki;Aizawa, Hisamichi
通讯作者：
Aizawa, Hisamichi

Correlation of decreased survival and IL-18 in bone metastasis.

DOI：
10.2169/internalmedicine.48.1851
发表时间：
2009
期刊：
Internal medicine
影响因子：
1.2
作者：
M. Okamoto;K. Azuma;T. Hoshino;H. Imaoka;Jiro Ikeda;T. Kinoshita;S. Takamori;K. Ohshima;N. Edakuni;S. Kato;T. Iwanaga;H. Aizawa
通讯作者：
M. Okamoto;K. Azuma;T. Hoshino;H. Imaoka;Jiro Ikeda;T. Kinoshita;S. Takamori;K. Ohshima;N. Edakuni;S. Kato;T. Iwanaga;H. Aizawa

Altered IL-4 effects by cellular interaction between vascular smooth muscle cells and macrophages : an in vitro study.

通过血管平滑肌细胞和巨噬细胞之间的细胞相互作用改变 IL-4 的作用：一项体外研究。