Role of nitric oxide in gastroduodenal pathogenesis following Helicobacter pylori infection

为探讨一氧化氮(NO)的产生与幽门螺杆菌感染的关系，以蒙古沙鼠为实验动物，进行了体外实验和体内实验。亚硝酸盐对幽门螺杆菌的杀菌作用强于硝酸盐。硝酸盐处理的沙土鼠和未处理的沙土鼠在幽门螺杆菌的定植数量上没有显著差异。硝酸盐处理的沙土鼠血浆和胃液中硝酸盐和亚硝酸盐的浓度显著高于未处理的沙土鼠。硝酸盐处理的沙土鼠的囊性扩张分数显著低于未处理的沙土鼠。这些结果提示，摄取含硝酸盐的食物可能调节幽门螺杆菌感染后胃粘膜的炎性变化。

To examine correlation between nitric oxide (NO) generation and Helicobacter pylori infection, in vitro experiment and in vivo experiment using Mongolian gerbil were performed. Nitrite was shown to indicate stronger bactericidal effect on H. pylori than nitrate. There was no significant difference in the number of H. pylori colonized between nitrate treated and untreated gerbils. Concentrations of nitrate and nitrite in plasma and gastric juice were significantly higher in nitrate-treated gerbils than those in untreated ones. Cystic dilatation score was significantly lower in nitrate-treated gerbils than that in untreated gerbils. These results suggest that uptake of nitrate-containing food might regulate inflammatory changes of gastric mucosa following H. pylori infection.