Sample Helicobacter Pylori

研究慢性胃炎和胃癌患者幽门螺杆菌与胃内微生物群的相关性。 结果表明，无论H. pylori是否感染，胃炎患者中链球菌均占优势，而仅在H. pylori阳性的胃炎患者中才检测到Atopobacter、Enterococcus和Lactobacillus。 胃癌患者的胃微生物群与幽门螺杆菌阴性胃炎患者相似。 宏基因组分析显示，幽门螺杆菌阳性和阴性胃炎患者中，奈瑟菌科、伯克霍尔德氏菌科和肠杆菌科、假单胞菌科分别是优势变形菌。 这些结果表明，幽门螺杆菌感染通过降低胃酸度来影响胃环境，从而影响其他胃微生物群的持续存在。

Correlation between Helicobacter pylori and gastric microbiota was examined for the patients with chronic gastritis and gastric cancer. It was shown that streptococci were dominant in the patients with gastritis regardless of H. pylori infection and that Atopobacterium, Enterococcus and Lactobacillus were detected only in the H. pylori positive gastritis patients. Gastric microbiota of the patient with gastric cancer was similar to that of H. pylori-negative gastritis patients. By meta-genome analysis, it was shown that Neisseriaceae, Burkholderiaceae and Enterobacteiaceae, Pseudomonadaceae were dominant Proteobacteria for the H. pylori positive and negative patients with gastritis, respectively. These results suggest that H. pylori infection affects gastric environments for persistence of other gastric microbiota by decreasing of gastric acidity.