The analysis of immune responses in humanized NOG mice

分析了人B淋巴细胞和T淋巴细胞在超免疫缺陷NOG小鼠体内重组后的免疫学特性。成熟的IGD+B细胞在体外对抗原和细胞因子刺激产生免疫球蛋白G。人源化NOG小鼠外周T细胞在抗原刺激下既不能增殖，也不能产生IL-2。这个问题与幼稚T细胞的频率降低和效应/记忆T细胞的频率增加有关。转基因表达的人类白细胞抗原DR并不能挽救NOG小鼠的T细胞功能。

The immunological features of the human B and T lymphocyteswere analyzed, which are reconstituted in super-immunodeficient NOG mice. The mature IgD+ B cells produced IgG in response to antigen and cytokine stimulation in vitro. The T cells in the periphery in the humanized NOG mice could neither proliferate nor produce IL-2 in response to antigenic stimulation. The problem is associated with the reduction of the frequency of naive T cells and the increase of that of effector/memory T cells. The transgenic expression of HLA-DR in NOG mice did not rescue the T cell function.