Physiological role of 11-dehydrothromboxane B2 : parameter of platelet activity and aspirin resistance
Physiological role of 11-dehydrothromboxane B2 : parameter of platelet activity and aspirin resistance
批准号:
20590573
负责人:
MATSUURA Eiji
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Aspirin prevents platelet aggregation by irreversible acetylation of cyclooxygenase. We evaluated the usefulness of an enzyme-linked immunosorbent assay (ELISA) to determine levels of 11-dehydrothromboxane B2 in urine, which aids in the detection of aspirin effect post ingestion. In low-density lipoprotein receptor-deficient mice fed with a high fat diet and received aspirin, urinary 11-dehydrothromboxane B2 (11-dhTXB2) tended to decrease and atherosclerotic plaque area significantly decreased.
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Angiostatin 4.5 (plasminogen Kringle 1-4.5)を介したnicked β2GPIの血管新生に与える影響
带切口的 β2GPI 通过血管抑制素 4.5(纤溶酶原 Kringle 1-4.5)对血管生成的影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[中川久子、保田晋介、松浦栄次, (他6名)]
通讯作者:
(他6名)
The immunology of atherosclerosis in the antiphospholipid syndrome : Antigen presentation and lipid intracellular accumulation
抗磷脂综合征中动脉粥样硬化的免疫学:抗原呈递和脂质细胞内积聚
DOI:
--
发表时间:
2009
期刊:
Autoimmune Rev (印刷中)
影响因子:
--
作者:
[Matsuura E, Kobayashi K, Matsunami Y, Lopez LR]
通讯作者:
Lopez LR
Atherosclerosis and angiogenesis in autoimmunity.
自身免疫中的动脉粥样硬化和血管生成。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[梅野真由美, 他, 松浦栄次]
通讯作者:
松浦栄次
DOI:
10.1177/0961203309106600
发表时间:
2009-11-01
期刊:
LUPUS
影响因子:
2.6
作者:
[Ayada, K., Yokota, K., Oguma, K.]
通讯作者:
Oguma, K.
Nicked{beta}2-glycoprotein I binds angiostatin 4.5(plasminogen kringle 1-5)and attenuates its antiangiogenic property.
带切口的 {β}2-糖蛋白 I 结合血管抑制素 4.5(纤溶酶原 kringle 1-5)并减弱其抗血管生成特性。
DOI:
--
发表时间:
2009
期刊:
Blood 114
影响因子:
--
作者:
[Nakagawa H, Yasuda S, Matsuura E, 他6名]
通讯作者:
他6名
共 14 条
Development of a novel radiological-photo-therapy essential for Theranostics targeting deep lesions
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批准号:16K15582
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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依托单位:
Development of targeted medical care (simultaneous diagnostic imaging and therapy) for pathogenic angiogenesis using fibrinolytic metabolites
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财政年份:2011
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Development of targeted therapy of cancer cells with diagnostic imaging through the application of immunoliposomes
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依托单位:
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负责人:MATSUURA Eiji
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依托单位:
A role of macrophages on antiphospholipid syndrome : antigen presenting and mechanisms on thrombosis
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项目类别:Grant-in-Aid for Scientific Research (C)
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负责人:MATSUURA Eiji
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依托单位:
海外基金