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Physiological role of 11-dehydrothromboxane B2 : parameter of platelet activity and aspirin resistance

Physiological role of 11-dehydrothromboxane B2 : parameter of platelet activity and aspirin resistance
11-脱氢血栓烷 B2 的生理作用:血小板活性和阿司匹林抵抗的参数
批准号:
20590573
负责人:
MATSUURA Eiji
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Aspirin prevents platelet aggregation by irreversible acetylation of cyclooxygenase. We evaluated the usefulness of an enzyme-linked immunosorbent assay (ELISA) to determine levels of 11-dehydrothromboxane B2 in urine, which aids in the detection of aspirin effect post ingestion. In low-density lipoprotein receptor-deficient mice fed with a high fat diet and received aspirin, urinary 11-dehydrothromboxane B2 (11-dhTXB2) tended to decrease and atherosclerotic plaque area significantly decreased.
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会议论文
Angiostatin 4.5 (plasminogen Kringle 1-4.5)を介したnicked β2GPIの血管新生に与える影響
带切口的 β2GPI 通过血管抑制素 4.5(纤溶酶原 Kringle 1-4.5)对血管生成的影响
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [中川久子、保田晋介、松浦栄次, (他6名)]
通讯作者: (他6名)
The immunology of atherosclerosis in the antiphospholipid syndrome : Antigen presentation and lipid intracellular accumulation
抗磷脂综合征中动脉粥样硬化的免疫学:抗原呈递和脂质细胞内积聚
DOI: --
发表时间: 2009
期刊: Autoimmune Rev (印刷中)
影响因子: --
作者: [Matsuura E, Kobayashi K, Matsunami Y, Lopez LR]
通讯作者: Lopez LR
Atherosclerosis and angiogenesis in autoimmunity.
自身免疫中的动脉粥样硬化和血管生成。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [梅野真由美, 他, 松浦栄次]
通讯作者: 松浦栄次
DOI: 10.1177/0961203309106600
发表时间: 2009-11-01
期刊: LUPUS
影响因子: 2.6
作者: [Ayada, K., Yokota, K., Oguma, K.]
通讯作者: Oguma, K.
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