Effects of kampo medicines on drug-resistance mediated by ABC transporter, MDR-1
Effects of kampo medicines on drug-resistance mediated by ABC transporter, MDR-1
批准号:
20590712
负责人:
HANAWA Toshihiko
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Drug resistance is a problem in the treatment of diseases, such as autoimmune disease and malignancy. MDR-1, a member of drug transporters, causes drug resistance via the exclusion of intracellular drugs. In this study, the kampo medicines suppressed the efflux function of MDR-1, suggesting that the resistance to anticancer drugs or steroidal antiinflammatory drugs may be overcomes by the medicines. The combined application of modern and traditional medicines is expected to be useful for the treatment of drug-refractory diseases.
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HGFにより誘導される乳癌細胞の運動能及びc-Metチロシンリン酸化の麻黄湯による抑制
maoto 抑制 HGF 诱导的乳腺癌细胞运动和 c-Met 酪氨酸磷酸化
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[日向須美子, ら]
通讯作者:
ら
Corticosteroid Sparing Effect of Hachimijiogan in Mikulicz's Disease:A Case Report
Hachimijiogan 对 Mikulicz 病的皮质类固醇节约作用:一例报告
DOI:
10.3937/kampomed.60.513
发表时间:
2009
期刊:
Kampo Medicine
影响因子:
--
作者:
[T. Tsuda, S. Yashiro, Yuji Gamo, W. Watanabe, T. Hoshino, S. Hyuga, T. Oikawa, T. Hanawa]
通讯作者:
T. Hanawa
がん細胞の薬剤耐性に対する漢方薬の作用~MDR-1に対する検討から~
中草药对癌细胞耐药性的影响~来自MDR-1的研究~
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[津田篤太郎, ら]
通讯作者:
ら
Suppression of motility of human breast cancer cells by human serum after intake of maoto
摄入maoto后人血清对人乳腺癌细胞运动的抑制
DOI:
10.11339/jtm.26.51
发表时间:
2009
期刊:
The American journal of Chinese medicine
影响因子:
--
作者:
[Hidenori Ito, S. Hyuga, M. Hyuga, Koji Watanabe, T. Tsuda, T. Oikawa, T. Hanawa]
通讯作者:
T. Hanawa
Maoto, a kampo medicine, suppresses the HGF-induced motility and scattering by directly inhibiting phosphorylation of MET
Maoto 是一种汉方药物,通过直接抑制 MET 磷酸化来抑制 HGF 诱导的运动和散射
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Hyuga, et al.]
通讯作者:
et al.
共 15 条
Application to molecular targeted therapy for non-small-cell lung cancer of kampo medicines having c-Met inhibitory activity
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批准号:24590896
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2012
-
负责人:HANAWA Toshihiko
-
依托单位:
Establishment of diagnostic system on Kampo Medicine with gene analysis.
-
批准号:16390160
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.54万
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财政年份:2004
-
负责人:HANAWA Toshihiko
-
依托单位:
Fundamental research of educational system and method of Oriental medicine on 21st century in Japan
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批准号:10470503
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.06万
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财政年份:1998
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负责人:HANAWA Toshihiko
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依托单位:
海外基金