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Effects of kampo medicines on drug-resistance mediated by ABC transporter, MDR-1

Effects of kampo medicines on drug-resistance mediated by ABC transporter, MDR-1
汉方药物对ABC转运蛋白MDR-1介导的耐药性的影响
批准号:
20590712
负责人:
HANAWA Toshihiko
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Drug resistance is a problem in the treatment of diseases, such as autoimmune disease and malignancy. MDR-1, a member of drug transporters, causes drug resistance via the exclusion of intracellular drugs. In this study, the kampo medicines suppressed the efflux function of MDR-1, suggesting that the resistance to anticancer drugs or steroidal antiinflammatory drugs may be overcomes by the medicines. The combined application of modern and traditional medicines is expected to be useful for the treatment of drug-refractory diseases.
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DOI: --
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DOI: 10.11339/jtm.26.51
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期刊: The American journal of Chinese medicine
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15
    Application to molecular targeted therapy for non-small-cell lung cancer of kampo medicines having c-Met inhibitory activity
    • 批准号:
      24590896
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.24万
    • 财政年份:
      2012
    • 负责人:
      HANAWA Toshihiko
    • 依托单位:
    Establishment of diagnostic system on Kampo Medicine with gene analysis.
    Fundamental research of educational system and method of Oriental medicine on 21st century in Japan
    • 批准号:
      10470503
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $5.06万
    • 财政年份:
      1998
    • 负责人:
      HANAWA Toshihiko
    • 依托单位:
    海外基金