Development of a Novel Therapeutic Strategy for Cardiovascular Disease With Use of Accelerating Bed

利用加速床开发心血管疾病的新型治疗策略

• 批准号: 20590824
• 负责人: FUJITA Masatoshi
• 金额: $ 3万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590824/
• 关键词: 加速ベッド; 動脈硬化; 狭心症; 糖尿病; 血管内皮機能; 運動耐容能; 血管内皮前駆細胞; Endo-PAT; 心不全; 心筋シンチグラフィ; トレッドミル負荷試験

The whole-body periodic acceleration (WBPA) bed has recently been developed as a "passive exercise" device by providing increased pulsatile shear stress for improvement of vascular endothelial function. In the present study, we evaluated the effects of the WBPA treatment on exercise tolerance in patients with chronic stable angina, coronary flow reserve in healthy subjects and patients with coronary artery disease, and vascular endothelial function in type 2 diabetic patients. In angina patients, 20 sessions of the WBPA treatment improved the treadmill exercise tolerance, myocardial perfusion at rest and during adenosine infusion, and left ventricular remodeling. Only one session of the WBPA treatment ameliorated coronary flow reserve in patients with coronary artery disease as well as in normal subjects. In type 2 diabetic patients, the impaired vascular endothelial function was augmented by 10 sessions of the WBPA treatment, and the improvement was associated with the increase in the number of endothelial progenitor cells. These promising results of the WBPA treatment provide a possibility that the treatment will be a novel therapeutic strategy for a variety of cardiovascular diseases.

全身周期性加速（WBPA）床最近被发展为一种“被动运动”装置，通过提供增加的脉冲剪切应力来改善血管内皮功能。在本研究中，我们评估了WBPA治疗对慢性稳定型心绞痛患者运动耐量、健康受试者和冠心病患者冠状动脉血流储备以及2型糖尿病患者血管内皮功能的影响。在心绞痛患者中，20次WBPA治疗改善了跑步机运动耐量、静息和腺苷输注时心肌灌注和左心室重构。只有一个疗程的双酚a治疗改善冠状动脉疾病患者和正常人的冠状动脉血流储备。在2型糖尿病患者中，经过10次WBPA治疗，受损的血管内皮功能得到增强，并且这种改善与内皮祖细胞数量的增加有关。这些有希望的结果为WBPA治疗多种心血管疾病提供了一种新的治疗策略。

项目成果

Noveltreatment with whole body periodic acceleration with a horizontal motion platform improves exercise capacity

水平运动平台全身周期性加速的新颖治疗方法提高运动能力

• 发表时间: 2009
• 作者: Miyamoto S;Inoko M;Haruna T;Oba M;Uehara K;Nakae E;Abe T;Sakaki K;Itoh H;Fukuda T;Nakashima J;Tanaka N;Ueyama K;Nohara R;Fujita M
• 通讯作者: Fujita M

Novel treatment with periodic accleration with a horizontal motion platform for anginal patients.

通过水平运动平台周期性加速治疗心绞痛患者的新型治疗方法。

• 发表时间: 2008
• 作者: Miyamoto S;Fujita M;et al.
• 通讯作者: et al.

Whole-body periodic accleration enhances brachial endothelial function.

全身周期性加速增强肱骨内皮功能。

• 发表时间: 2008
• 期刊: Circulation Journal 72(1)
• 作者: Matsumoto T;Fujita M;et al.
• 通讯作者: et al.

Whole-body periodic acceleration mobilizes CD34^+/KDR^+ cells in type 2 diabetic patients.

全身周期性加速可动员 2 型糖尿病患者的 CD34^ /KDR^ 细胞。

• 发表时间: 2010
• 作者: Takahashi Y;Fujita M;et al.
• 通讯作者: et al.

Acute effect of whole-body periodic acceleration on brachial flow-mediated vasodilation assessed by a novel semi-automatic vessel chasing system of UNEXEF18G.

通过 UNEXEF18G 的新型半自动血管追踪系统评估全身周期性加速对肱动脉血流介导的血管舒张的急性影响。

• 发表时间: 2010
• 作者: Takase B;Nagata M;Fujita M
• 通讯作者: Fujita M