Immunomodulationtherapyagainstdilatedcardiomyopathy

针对扩张型心肌病的免疫调节疗法

• 批准号: 20590852
• 负责人: BABA Akiyasu
• 金额: $ 2.25万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590852/
• 关键词: 拡張型心筋症; 免疫吸着療法; 心筋自己抗体

Some DCM (dilated cardiomyopathy) patients have autoantibodies against their heart, which we can remove from the body by immunoadsorption therapy. This study discovered a characteristic of the patient whom this therapy worked for well. When we completely removed autoantibodies from the body by this treatment, the cardiac function get better. Even if autoantibodies increase again in the body, and the cardiac function reverses, we may perform the immunoadsorption many times.

一些DCM（扩张型心肌病）患者有针对心脏的自身抗体，我们可以通过免疫吸附治疗将其从体内清除。这项研究发现了一个特点的病人，这种疗法的工作。当我们通过这种治疗完全清除了体内的自身抗体时，心脏功能会变得更好。即使体内自身抗体再次增加，心脏功能逆转，我们也可以多次进行免疫吸附。

项目成果

A pilot study on the role of autoantibody targeting the betal-adrenergic receptor in the response to beta-blocker therapy for congestive heart failure.

一项关于针对β-肾上腺素能受体的自身抗体在充血性心力衰竭的β-受体阻滞剂治疗反应中的作用的初步研究。

• 发表时间: 2009
• 期刊: J Card Fail 15
• 作者: Nagatomo Y;Yoshikawa T;Kohno T;Yoshizawa A;Baba A;et al.
• 通讯作者: et al.

心不全のアフェレシス(招待講演)

心力衰竭的血浆分离术（特邀报告）

• 发表时间: 2010
• 作者: Li M;Zheng C;Kawada T;Inagaki M;Uemura K;Shishido T;Akiyama T;Sugimachi M.;馬場彰泰
• 通讯作者: 馬場彰泰

Anti-myocardial autoantibodies in hemodialysis patients

血液透析患者抗心肌自身抗体的检测

• 发表时间: 2010
• 作者: Yuri Rokumaru;Akiyasu Baba;Makoto Akaishi;Megumi Shimada
• 通讯作者: Megumi Shimada

Specific Immunoadsorption Therapy Using a Tryptophan Column in Patients with Refractory Heart Failure Due to Dilated Cardiomyopathy

• DOI: 10.1002/jca.20268
• 发表时间: 2011-01-01
• 期刊: JOURNAL OF CLINICAL APHERESIS
• 影响因子: 1.5
• 作者: Nagatomo, Yuji;Baba, Akiyasu;Yoshikawa, Tsutomu
• 通讯作者: Yoshikawa, Tsutomu

Complete Elimination of Cardiodepressant IgG3 Autoantibodies by Immunoadsorption in Patients With Severe Heart Failure

• DOI: 10.1253/circj.cj-09-0748
• 发表时间: 2010-07-01
• 期刊: CIRCULATION JOURNAL
• 影响因子: 3.3
• 作者: Baba, Akiyasu;Akaishi, Makoto;Yoshikawa, Tsutomu
• 通讯作者: Yoshikawa, Tsutomu