Development of intracoronary imaging system to predict and stabilize unstable coronary plaque

开发冠状动脉内成像系统来预测和稳定不稳定的冠状动脉斑块

• 批准号: 20590849
• 负责人: OKURA Hiroyuki
• 金额: $ 3.08万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590849/
• 关键词: 冠動脈; 不安定プラーク; 血管内超音波; 光干渉断層法; 虚血性心疾患; 動脈硬化; 血管内光干渉断層法; 急性冠症候群; 糖尿病

To investigate plaque characteristics and serial changes in coronary arterial plaque of unstable or vulnerable plaque, intravascular ultrasound (IVUS) and optical coherence tomography (OCT) imaging were performed in patient with coronary artery disease. IVUS-derived tissue characterization revealed that predominant plaque component of the thin-cap fibroatheroma was lipid pool. In addition, positive arterial remodeling contributed to progressive thinning of the fibrous cap.

为探讨冠状动脉不稳定斑块或易损斑块的斑块特征及斑块的动态变化，对10例冠心病患者行血管内超声（IVUS）和光学相干断层扫描（OCT）检查。IVUS衍生的组织表征显示，薄帽纤维粥样硬化的主要斑块成分是脂质池。此外，积极的动脉重塑有助于纤维帽的进行性变薄。

项目成果

Relationship between arterial and fibrous cap remodeling : a serial three-vessel intravascular ultrasound and optical coherence tomography study.

动脉和纤维帽重塑之间的关系：连续三血管血管内超声和光学相干断层扫描研究。

• 发表时间: 2010
• 期刊: Circ Cardiovasc Intervent Vol.3, No.2
• 作者: Yamada R;Okura H;Kume T;Saito K;Miyamoto Y;Imai K;Tsuchiya T;Maehama T;Okahashi N;Obase K;Hayashida A;Neishi Y;Kawamoto T;Yoshida K
• 通讯作者: Yoshida K

Changes in Fibrous Cap Thickness in Diabetic and Non-diabetic Patients : A Serial Optical Coherence Tomography Study

糖尿病和非糖尿病患者纤维帽厚度的变化：系列光学相干断层扫描研究

• 发表时间: 2010
• 作者: Yamada R;Okura H;Yoshida K;et al.
• 通讯作者: et al.

Relationship between arterial and fibrous cap remodeling : a serial three-vessel intravascular ultrasound and optical coherence tomography study

动脉和纤维帽重塑之间的关系：连续三血管血管内超声和光学相干断层扫描研究

• 发表时间: 2010
• 期刊: Circulation : Cardiovascular Interventions
• 作者: Yamada R;Okura H;Kume T;Saito K;Miyamoto Y;Hayashida A;Yoshida K;et al.
• 通讯作者: et al.

光干渉断層法とintegrated backscatter intravascular ultrasound によるthin cap fibroaheromaの診断.

使用光学相干断层扫描和集成反向散射血管内超声诊断薄帽纤维粥样硬化。

• 发表时间: 2009
• 作者: 宮本欣倫、大倉宏之、根石陽二、川元隆弘、吉田清;ほか
• 通讯作者: ほか

Plaque Characteristics of Thin Cap Fibroatheroma evaluated by Optical Coherence Tomography and Integrated Backscatter Intravascular Ultrasound.

通过光学相干断层扫描和集成反向散射血管内超声评估薄帽纤维粥样斑块特征。

• 发表时间: 2011
• 期刊: JACC Cardiovasc Img (in press)
• 作者: Miyamoto Y;Okura H;Kume T;Kawamoto T;Neishi Y;Hayashida A;Yamada R;Imai K;Saito K;Yoshida K
• 通讯作者: Yoshida K