Role of connexin-43 in protective signaling incardiomyocyte

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This study aimed to clarify role of connexin-43 (Cx43) in a major cytoprotective signaling, PI3K-Akt-GSK-3β signaling in cardiomyocytes. We found that Cx43 in the sarcolemma contributes to activation of class I_B P13K as a co-factor of β subunit of G proteins. This role of Cx43 is specific to regulation of class I_B P13K and is not required for activation of class I_A PI3K. Cx43 in mitochondria, being necessary for redox signaling by activated mitochondrial ATP-sensitive K^+ channel, was found to be dispensable in PI3K-Akt-GSK-3β signaling by G-protein coupled receptors.