Development of new treatment for atherosclerosis by regulating cell-mediated immunity

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We investigated the role of cell-mediated immunity on the mechanism of arterioscelrosis using mouse models of cardiac allograft transplantation and wire-induced injury of the femoral artery. We paid attention to MMP-9, ICAM-1, and adiponectin as mediators or suppressors of arteriosclerosis in these models. Clarithromycin which suppresses MMP-9 activity and siRNA ICAM-1 were effective in suppressing arterial lesions and adiponectin over expression mouse showed lesser extent of chronic allograft rejection. These results indicate the role of immunity and inflammation on the arterioscelrosis and these new agents may be useful as new targets for prevention of clinical diseases.