Common pathological background of chronic kidney disease and life-habit associated metabolic disorders

慢性肾脏病和生活习惯相关代谢紊乱的常见病理背景

• 批准号: 20590941
• 负责人: NAKAYAMA Masaaki
• 金额: $ 2万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590941/
• 关键词: 腎臓学; 慢性腎臓病; メタボリック症候群; 生活習慣病; 糖代謝産物; メチルグリオキサール; ギ酸

Chronic kidney disease (CKD) and life-style related metabolic disorders such as hypertension, and diabetes, are independent risk factors for excess cardiovascular events, however the common pathological mechanisms or causative molecules have remained to be addressed. The present study identified glucose degraded molecule ? methylglyoxal as one of the candidates. Methylglyoxal induces cellular and organ damage by enhancing oxidative stress. Furthermore, it was suggested that the degraded process of methylglyoxal may facilitate purine metabolism, leading to uric acid production.

慢性肾脏病（CKD）和高血压、糖尿病等生活方式相关的代谢紊乱是心血管事件发生的独立危险因素，但其共同的病理机制或致病分子仍有待研究。本研究确定了葡萄糖降解分子？丙酮醛作为候选物之一。丙酮醛通过增强氧化应激诱导细胞和器官损伤。此外，有人认为，甲基乙二醛的降解过程中可能会促进嘌呤代谢，导致尿酸的产生。

项目成果

メチルグリオキサールによる尿酸代謝の影響

甲基乙二醛对尿酸代谢的影响

• 发表时间: 2010
• 作者: 加藤順一郎、中山昌明;伊藤貞嘉;ら
• 通讯作者: ら

Biological Effect of Electrolyzed Water on Human Neutrophils and Clinical Application to Hemodialysis Treatment.

电解水对人体中性粒细胞的生物学效应及其在血液透析治疗中的临床应用。

• 发表时间: 2009
• 期刊: Nephron Clin Pract 112
• 作者: Nakayama M;et al.
• 通讯作者: et al.

Carbonated soft drinks and carbonyl stress burden.

• DOI: 10.2131/jts.34.699
• 发表时间: 2009-12
• 期刊: The Journal of toxicological sciences
• 作者: Keisuke Nakayama;M. Nakayama;H. Terawaki;Yaeko Murata;Toshinobu Sato;M. Kohno;S. Ito

characteristic effect of methylglyoxal and its degraded product formate on viability of human histiocytes : A possible detoxification pathway of methylglyoxal.

甲基乙二醛及其降解产物甲酸盐对人类组织细胞活力的特征性影响：甲基乙二醛可能的解毒途径。

• 发表时间: 2011
• 期刊: Biochem Bioph Res Commun 407
• 作者: Koizumi K;Nakayama M;Zhu WJ;Ito S.
• 通讯作者: Ito S.

Oxidative stress enhances cytotoxicity of methylglyoxal and its chemical degradation to formic acid : relevance to uremic pathology

氧化应激增强甲基乙二醛的细胞毒性及其化学降解为甲酸：与尿毒症病理学的相关性

• 发表时间: 2008
• 作者: 永井大樹;浅井圭介;Masaaki Nakayama
• 通讯作者: Masaaki Nakayama