Pathological involvement of carbonyl stress for development of cognitive impairment in CKD

羰基应激与 CKD 认知障碍发展的病理学关系

• 批准号: 23591196
• 负责人: NAKAYAMA Masaaki
• 金额: $ 3.41万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591196/
• 关键词: 慢性腎臓病; 認知機能; 尿毒素; メチルグリオキサール; カルボニルストレス; 抗酸化療法; 水素水

Recent clinical studies have demonstrated the close associations of cognitive impairment (CI) with plasma methylglyoxal (MG) levels and presence of kidney dysfunction. Tthe present study aims to examine whether MG is a direct causative substance for CI development. Experimental rats were divided into two groups: control and MG group (0.5% MG in drinking water), and fed a normal diet for 12 months. Cognitive function was evaluated by two behavioral tests. Serum MG was significantly elevated in the MG group at the end of study. The groups did not differ in cognitive function during the course of study. No time-course differences were found in oxidative stress markers between the two groups, while, antioxidants were significantly increased in the MG group. Long-term MG administration to rats with normal kidney did not cause CI, possibley due to a counter-balanced activation of the anti-oxidant system. Pathogenetic significance of MG for CI requires further investigation.

最近的临床研究表明，认知障碍（CI）与等离子体甲基乙二醇（MG）水平的紧密关联以及肾功能障碍的存在。本研究旨在检查MG是否是CI发育的直接病因。将实验大鼠分为两组：对照组和MG组（饮用水中的0.5％mg），并喂养正常饮食12个月。通过两个行为测试评估认知功能。在研究结束时，MG组的血清MG显着升高。在研究过程中，这些小组在认知功能方面没有差异。两组之间的氧化应激标记中未发现时间课程差异，而Mg组的抗氧化剂显着增加。长期对患有正常肾脏的大鼠的长期毫克给药不会引起CI，这可能是由于抗氧化剂系统的平衡激活而可能导致的。 MG对CI的致病意义需要进一步研究。

项目成果

Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats.

• DOI: 10.1093/ndt/gfq727
• 发表时间: 2011-07
• 期刊: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
• 作者: Wanjun Zhu;M. Nakayama;Takefumi Mori;Keisuke Nakayama;Junichiro Katoh;Yaeko Murata;Toshinobu Sato;S. Kabayama;S. Ito

Methylglyoxal (MG) and cerebro-renal interaction: does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?

• DOI: 10.3390/toxins6010254
• 发表时间: 2014-01-07
• 期刊: Toxins
• 影响因子: 4.2
• 作者: Watanabe K;Okada K;Fukabori R;Hayashi Y;Asahi K;Terawaki H;Kobayashi K;Watanabe T;Nakayama M
• 通讯作者: Nakayama M

２． 尿毒症物質メチルグリオキサールによる認知機能障害に関する研究

2.

• 作者: 渡邉 公雄;林 義満;旭 浩一;深堀 良二;岡田 佳奈;小林 和人;中山 昌明;渡辺 毅
• 通讯作者: 渡辺 毅

尿毒症物質メチルグリオキサールによる認知機能障害に関する研究

尿毒症物质甲基乙二醛引起认知功能障碍的研究

• 发表时间: 2013
• 作者: 渡邉公雄;林義満;旭浩一;深堀良二;岡田佳奈;小林和人;中山昌明;渡辺毅
• 通讯作者: 渡辺毅

Increased risk of cardiovascular events and mortality among non-diabetic chronic kidney disease patients with hypertensive nephropathy

患有高血压肾病的非糖尿病慢性肾病患者心血管事件和死亡的风险增加

• 发表时间: 2011
• 期刊: Hypertens Res
• 影响因子: 5.4
• 作者: Nakayama M;Sato T;Miyazaki M;Matsushima M;Sato H;Taguma Y;Ito S.
• 通讯作者: Ito S.