Pathological involvement of carbonyl stress for development of cognitive impairment in CKD

羰基应激与 CKD 认知障碍发展的病理学关系

• 批准号: 23591196
• 负责人: NAKAYAMA Masaaki
• 金额: $ 3.41万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591196/
• 关键词: 慢性腎臓病; 認知機能; 尿毒素; メチルグリオキサール; カルボニルストレス; 抗酸化療法; 水素水

Recent clinical studies have demonstrated the close associations of cognitive impairment (CI) with plasma methylglyoxal (MG) levels and presence of kidney dysfunction. Tthe present study aims to examine whether MG is a direct causative substance for CI development. Experimental rats were divided into two groups: control and MG group (0.5% MG in drinking water), and fed a normal diet for 12 months. Cognitive function was evaluated by two behavioral tests. Serum MG was significantly elevated in the MG group at the end of study. The groups did not differ in cognitive function during the course of study. No time-course differences were found in oxidative stress markers between the two groups, while, antioxidants were significantly increased in the MG group. Long-term MG administration to rats with normal kidney did not cause CI, possibley due to a counter-balanced activation of the anti-oxidant system. Pathogenetic significance of MG for CI requires further investigation.

最近的临床研究表明，认知功能障碍（CI）与血浆甲基乙二醛（MG）水平和肾功能障碍的存在密切相关。本研究旨在探讨MG是否是CI发展的直接原因。实验大鼠分为对照组和MG组（0.5% MG饮水），正常饮食喂养12个月。认知功能通过两项行为测试进行评估。研究结束时MG组血清MG水平显著升高。在研究过程中，各组的认知功能没有差异。两组之间的氧化应激指标无时间过程差异，而MG组的抗氧化剂显著增加。长期MG给药与正常肾脏的大鼠没有引起CI，可能是由于反平衡激活的抗氧化系统。MG对CI的发病意义需要进一步研究。

项目成果

Peritoneal clearance and transport of methylglyoxal.

甲基乙二醛的腹膜清除和转运。

• 发表时间: 2011
• 期刊: Nephrol Dial Transplant
• 作者: 藤田純一;川口未央;國分二三男;松倉聡;森島祐子;石井幸雄;坂本透;足立満;檜澤伸之;Hiroyuki Terawaki
• 通讯作者: Hiroyuki Terawaki

Characteristic effects of methylglyoxal and its degraded product formate on viability of human histiocytes: a possible detoxification pathway of methylglyoxal.

• DOI: 10.1016/j.bbrc.2011.03.041
• 发表时间: 2011-04
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: K. Koizumi;M. Nakayama;Wanjun Zhu;S. Ito

Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats.

• DOI: 10.1093/ndt/gfq727
• 发表时间: 2011-07
• 期刊: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
• 作者: Wanjun Zhu;M. Nakayama;Takefumi Mori;Keisuke Nakayama;Junichiro Katoh;Yaeko Murata;Toshinobu Sato;S. Kabayama;S. Ito

２． 尿毒症物質メチルグリオキサールによる認知機能障害に関する研究

2.

• 作者: 渡邉 公雄;林 義満;旭 浩一;深堀 良二;岡田 佳奈;小林 和人;中山 昌明;渡辺 毅
• 通讯作者: 渡辺 毅

Methylglyoxal (MG) and cerebro-renal interaction: does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?

• DOI: 10.3390/toxins6010254
• 发表时间: 2014-01-07
• 期刊: Toxins
• 影响因子: 4.2
• 作者: Watanabe K;Okada K;Fukabori R;Hayashi Y;Asahi K;Terawaki H;Kobayashi K;Watanabe T;Nakayama M
• 通讯作者: Nakayama M