The role of hemoglobin receptor protein from Porphyromonas gingivalis on periodontitis

本研究旨在阐明牙龈卟啉单胞菌血红蛋白受体（HbR）蛋白在宿主上皮细胞上的功能及其与牙周炎的关系。使用牙龈上皮细胞系Ca 9 -22和原代牙龈上皮细胞，HbR蛋白在刺激后至少3小时内诱导白细胞介素-8。进一步揭示了HbR蛋白通过激活p38/CREB、Erk 1/2/ATF-2、NF-κ B等介导IL-8产生的分子机制。

In this study, we attempted to clarify about the function of hemoglobin receptor (HbR) protein from Porphyromonas gingivalis on the host epithelial cells and the relationship with inflammation in the periodontal diseases. Using gingival epithelial cell line Ca9-22 and primary gingivali epithelial cells, HbR protein induce interleukin-8 within at least 3 h after stimulation. Moreover, we revealed the molecular mechanisms by which HbR protein induced IL-8 production through the activation of p38/CREB and Erk1/2/ATF-2, NF-kB Therefore, these results led us to the possibility that HbR protein is associated with periodontitis by innate immun responses.