Physiological significance of phosphatidylinositol 3-kinase complexes

磷脂酰肌醇3-激酶（PI3K）产生磷脂酰肌醇3-磷酸，这是一种信号脂质，是多种生物途径（如自噬和内吞作用）所必需的。在植物中，PI3K复合物在细胞活动中的作用仍然不清楚，因为迄今为止没有PI3K突变体存在。在本研究中，创建了6株纯合子植株，这些植株表现出严重的生长缺陷。该突变体可作为进一步研究植物PI3K复合物生理功能的模型系统。

Phosphatidylinositol 3-kinase (PI3K) produces phosphatidylinositol3-phosphate, a signaling lipid required for various biological pathways, suchas autophagy and endocytosis. In plants, the roles of PI3K complexes in cellularactivities remain obscure, because no pi3k mutant is viable to date. In this study, Icreated atatg6 homozygous plants, which exhibited severe growth defects. This mutantshould serve as a model system for further investigating the physiological functions ofplant PI3K comple xes.