Regulatory role of nucleo-cytoplasmic transport in microtubule network organization

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In fission yeast cells as well as almost all eukaryotic cells, dynamic rearrangement of microtubule structure occurs at the cell cycle transition. I proposed that nucleo-cytoplasmic transport plays a central role in spatio-temporally regulated microtubule network organization. In this model, tubulin and tubulin-associated proteins are actively exported toward outside of the nucleus during interphase, and cytoplasmic microtubule formation is promoted by 'interphase microtubule organizing center', while they imported into the nucleus and mitotic spindle formation is promoted by mitotically activated spindle pole bodies.