Temporal and spatial regulation of competence in ascidian embryonic induction

海鞘胚胎诱导能力的时空调节

• 批准号: 20770178
• 负责人: KUMANO Gaku
• 金额: $ 2.75万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20770178/
• 关键词: 初期発生; ホヤ; 誘導; 応答能

Molecular mechanisms by which signal-receiving cells respond to the same inductive signal differently to make different tissue types in development were analyzed using ascidian embryos. We found that posteriorly-localized maternal PEM makes different competence factor expression between the anterior and posterior regions of the embryo and that these region (or cell)-specific competence factors in cooperation with the inductive signal generate different tissue types. In addition, we identified FoxB as a factor responsible for the loss of competence to the above inductive signal.

利用海鞘胚胎分析了信号接收细胞对相同诱导信号的不同反应，从而在发育中形成不同组织类型的分子机制。我们发现，后定位的母体PEM使不同的感受态因子表达之间的前部和后部区域的胚胎和这些区域（或细胞）特异性的感受态因子与诱导信号产生不同的组织类型。此外，我们确定FoxB作为一个因素，负责上述诱导信号的能力的损失。

项目成果

Macho-1 regulates unequal cell divisions independently of its function as a muscle determinant

• DOI: 10.1016/j.ydbio.2010.05.013
• 发表时间: 2010-08-01
• 期刊: DEVELOPMENTAL BIOLOGY
• 影响因子: 2.7
• 作者: Kumano, Gaku;Kawai, Narudo;Nishida, Hiroki
• 通讯作者: Nishida, Hiroki

Molecular basis of loss of competence to the FGF signal in ascidian notochord induction

海鞘脊索诱导过程中 FGF 信号能力丧失的分子基础

• 发表时间: 2009
• 作者: Hashimoto;H.;Enomoto;A.;Kumano;G.;Nishida;H.
• 通讯作者: H.

マボヤ初期発生におけるTwist-like遺伝子の発現・機能解析

Maboya早期发育过程中Twist样基因的表达及功能分析

• 发表时间: 2009
• 作者: Kobayashi;M.;Hiroki Nishida;Gaku Kumano;Naohito Takatori;Takefumi Negishi;Hidehiko Hashimoto;Hiroki Nishida;Hidehiko Hashimoto;藤川徹也;児玉仁
• 通讯作者: 児玉仁

Wnt5 is required for notochord cell intercalation in the ascidian Ha/ocynthia roretzi

海鞘 Ha/ocynthia roretzi 脊索细胞嵌入需要 Wnt5

• 发表时间: 2009
• 期刊: Biol.Cell 101
• 作者: Niwano;T.
• 通讯作者: T.

Analysis of the expression of Lhx3 genes in two ascidian species, Halocynthia roretzi and Clona in testinalis

Lhx3基因在两种海鞘中Halocynthia roretzi和Clona的表达分析

• 发表时间: 2009
• 作者: Kobayashi;M.
• 通讯作者: M.