Evaluation of oxygen sensing mechanism(s) in lactic acid bacterial
Evaluation of oxygen sensing mechanism(s) in lactic acid bacterial
批准号:
20780060
负责人:
YAMAMOTO Yuji
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
In this study we investigated the oxygen sensing mechanism(s) in lactic acid bacteria, and identified Spx homologues (SpxA and SpxB), which are known as RNA-binding protein of Bacillus subtilis, as regulators required for oxygen-dependent induction of antioxidants in Streptococcus mutans. The spxA and spxB defective mutant of S. mutans was shown to lose the abilities to induce the expression of antioxidants and to grow under aerobic conditions. We also purified recombinant SpxA and SpxB proteins and constructed an assay system to distinguish oxidized- and reduced-form of the proteins.
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口腔内連鎖球菌Streptococcus mutansにおけるレドックスセンサーの同定
口腔变形链球菌氧化还原传感器的鉴定
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Kawashima C, Kida K, Schweigert FJ, Miyamoto A., 木村真ら, 青木麻智子ら]
通讯作者:
青木麻智子ら
細胞にとっての必要悪?-シグナル分子としての過酸化水素の役割-
它是细胞的必然之恶吗? -过氧化氢作为信号分子的作用-
DOI:
--
发表时间:
2010
期刊:
日本生物工学会誌 87巻
影响因子:
--
作者:
[Ishikawa S, Suzuki K, Fukuda E, Arihara K, Yamamoto Y, Mukai T, Itoh M, 山本裕司]
通讯作者:
山本裕司
Streptococcusmutansの酸素感知機構におけるSpxとPerRの役割
Spx和PerR在变形链球菌氧传感机制中的作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[山本裕司, ら他3名]
通讯作者:
ら他3名
Streptococcus mutansの酸素感知機構におけるSpxとPerRの役割
Spx和PerR在变形链球菌氧传感机制中的作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[山本裕司, ら]
通讯作者:
ら
DOI:
10.1016/j.febslet.2009.12.041
发表时间:
2010-02-19
期刊:
FEBS LETTERS
影响因子:
3.5
作者:
[Ishikawa, Shin-ichi, Suzuki, Kazuto, Itoh, Makoto]
通讯作者:
Itoh, Makoto
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