The development of chemohypethermia using magnetoliposomes in magnetic field

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In a previous study, we investigated electromagnetic heating with magnetite-loaded liposomes for the purpose of mild ablation in cancer treatment. The principal aim of this study was to determine whether the therapeutic efficacy of magnetite-loaded liposomes could be enhanced by attracting our liposomes containing magnetite to the tumor with magnet. Nude mice with TE-8 cells mimicking human esophageal cancer were treated by induction heating. To investigate the influence of this method on tumor growth, nude mice were assigned to 3 experimental groups: heating group (magnet), heating group (no magnet), and control group. In the heating group (magnet), magnetite-loaded liposomes were attracted to the tumor with a magnet and tumor-bearing mice placed for 10 min under an alternating magnetic field (AMF) after magnetite-loaded liposomes injection, while in the heating group (no magnet), magnetite-loaded liposomes were injected into each animal in absence of magnet and AMF treatment was administered. Tumor volume was significantly different between the control group and the other groups. Furthermore, the magnetite-loaded liposomes could be detected clearly in the tumor 3 days after treatment in heating groups (magnet). Thus, this new ablation method may be a feasible technique for cancer therapy.