Synthetic studies on polycyclic alkaloids through carbamoyl metal complexes.

由于多环生物碱具有广泛的生物活性，因此从药学的角度来看，这类化合物的合成研究是一项重要的任务。本课题研究了一种利用氨基甲酰基金属配合物合成多环生物碱的新方法。因此，从具有烯烃的氯代甲酰胺和氰基甲酰胺开始的内酰胺形成反应已经被开发，并且被应用于多环生物碱的合成。

Since polycyclic alkaloids are known to exhibit a broad range of important bioactivities, synthetic study of this class of compounds is an important task from pharmaceutical point of view. In this project, we studied a new method to approach polycyclic alkaloids by using carbamoyl metal complexes. As a result, lactam formation reaction starting from chloroformamides and cyanoformamides having olefin has been developed, and was applied to the syntheses of polycyclic alkaloids.